Background:
Among the millions of people around the world, the most prevalent metabolic
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially available
antidiabetic agents, new therapeutic approaches are needed to be considered. Alpha-amylase is a membrane-
bound enzyme which is responsible for the breakdown of polysaccharides such as starch to
monosaccharides which can be absorbed.
Methods:
We searched the scientific database using alpha-amylase, diabetes, antidiabetic agents as the
keywords. Here in, only peer-reviewed research articles were collected which were useful to our current
work.
Results:
To overcome the research gap, the alpha-amylase enzyme is regarded as a good target for antidiabetic
agents to design the drug and provide an alternate approach for the treatment of type 2 diabetes
mellitus. Basically, alpha-amylase inhibitors are classified into two groups: proteinaceous inhibitors,
and non-proteinaceous inhibitors. Recently, non-proteinaceous inhibitors are being explored
which includes chalcones, flavones, benzothiazoles, etc. as the potential antidiabetic agents.
Conclusion:
Herein, we discuss various potential antidiabetic agents which are strategically targeted
alpha-amylase enzyme. These are having lesser side effects as compared to other antidiabetic agents,
and are proposed to prevent the digestion and absorption of glucose leading to a decrease in the blood
glucose level.
Aim:
We aimed to review the drug delivery approaches including novel drug delivery system of doxorubicin as an important anticancer drug.
Background:
Doxorubicin is widely used against breast, uterine, ovarian, lung and cervical cancer. It is listed among the essential medicines by WHO and is thus a very important drug that can be used to fight against cancer. Despite its effectiveness, the use of the drug is limited due to its dose-dependent toxicity. Several studies based on the Doxorubicin have been suggesting the need of novel drug delivery formulations in the treatment of malignant and cancerous diseases due to its cytotoxic nature.
Objectives:
This review focuses on the different formulations of doxorubicin which is a useful drug in the management of cancers, but associated with toxicity thus these approaches found applicability in the reduction of its toxicity.
Methods:
We searched the scientific database using cancer, doxorubicin, and different formulations as the keywords. Here in only peer-reviewed research articles collected which were useful to our current work.
Conclusion:
In the review, we described the significance of doxorubicin in the form of different delivery approaches in the management cancers with the reduction in the associated toxicity.
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