The absorbance of a free-standing ultrathin layer is limited to 50%; we overcome this limitation by numerically investigating a wavelength-selective perfect absorber based on Mie resonance and degenerate critical coupling. We extend the wavelength of close-to-unity absorbance to the entire visible region by controlling the radiative loss and intrinsic loss. Radiative loss can be controlled by embedding the Mie resonator into a thin film with the defined refractive index. Meanwhile, intrinsic loss can be controlled by addition of a dielectric cap with a higher extinction coefficient on the Mie resonator. Such all-dielectric perfect absorbers can be applied to efficient photodetectors, imaging sensor pixels, or all-optical switching devices mediated by the photothermal effect.
In principle, the absorbance of a free-standing ultra-thin film is limited to 50%. To overcome this limitation, an all-dielectric perfect absorber is proposed herein based on the concept of degenerate critical coupling (DCC) of quadrupole modes. We study the absorbance of a dielectric elliptic cylinder and find that perfect absorption can be achieved by spectrally overlapping peaks of electric and magnetic quadrupole modes. This suggests that the DCC method can be extended to the quadrupole modes beyond dipole modes. Such an all-dielectric perfect absorber can be used in photodetectors, optical filters, and optical modulators mediated by the photothermal effect.
The low response rate to immunosuppressant is mainly due to the lack of adequate knowledge about the tumor microenvironment (TME) and screening biomarkers for gliomas. We aimed to identify the promising immune biomarkers and new immune classification of glioma. In this study, multiple‐immune algorithms were used to calculate immune‐infiltration scores. Unsupervised and supervised machine learning methods were used to perform the classification. We observed that OLFML3 overexpression was indicated in gliomas and linked to poor prognosis. OLFML3 knockdown inhibited proliferation, invasion and increased the sensitivity of glioma cells to temozolomide. OLFML3 expression could also reflect the aberrant immune status. Based on the immune‐related signature, patients were divided into three immune subtypes via consensus clustering. Patients with C2 subtype presented poorer prognosis and shorter progression free survival than patients with other two subtypes. The TME patterns among subtypes were different. C2 and C3 subtypes are the immune‐inflamed and immune‐desert tumors, respectively. Additionally, compared with C3 subtype, patients with C1/C2 subtypes were more likely to respond to immunotherapy. The pRRophetic algorithm indicated patients with C1/C2 subtypes were more resistant to temozolomide, but sensitive to paclitaxel and cisplatin. To conclude, OLFML3 overexpression affects glioma cell proliferation, invasion, and TMZ sensitivity and has been proved to be an independent prognostic‐ and immune‐related biomarker. Additionally, the novel immune subtype's classification could provide the prognostic and predictive predictors for glioma patients and may guide physicians in selecting potential responders.
Silicon metasurfaces have been attracting interest in the sensing field because of their ability to support magnetic Mie resonance, low optical heating, and CMOS-compatible fabrication processes. Herein, we demonstrate that the sensitivity of the magnetic dipole (MD) mode for nanodisk Mie resonators (as high as 385 nm/RIU) is similar to the sensitivity of plasmonic metasurfaces and greater than that of the electric dipole (ED) mode of nanodisk Mie resonators. We also engineer the thickness of Mie resonators to achieve an MD-mode linewidth as small as 0.56 nm and a figure of merit greater than 160 RIU−1. The measured sensitivity of the MD mode is more accurate than that of the ED mode, which is more prone than the MD mode to measurement errors arising from the partial filling of the liquid. Our study paves the way for the development of MD-mode-based dielectric biosensors for use in personal healthcare and medical diagnosis.
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