Dear Sir, We thank I. Catucci et al. (in preparation) for performing a replication study on the two ultraconserved element (UCE) variants rs2056116 and rs9572903 by analyzing an Italian study population of familial breast cancer cases. Beforehand, we had analyzed different single-nucleotide polymorphism (SNPs) in UCEs and found the variant rs2056116 to be associated with familial breast cancer risk especially in the (premenopausal) early age group investigating a German study population (1). Catucci et al., however, did not find any association of this variant with familial breast cancer although the inclusion criteria for the familial BRCA1/2 mutation-negative breast cancer cases were quite similar to ours.Interestingly, the allele frequencies of this variant were significantly different in the investigated German and Italian study populations. The minor allele frequency (MAF) in German control population is 0.39, whereas the MAF is 0.34 in the Italian control population (P 5 0.00007). Remarkably, Ban et al. (2) analyzed this SNP in 938 British trio families (an affected individual and both parents) for an influence on multiple sclerosis risk. Here, the MAF was 0.39 matching the allele frequency from our German study population. Thus, the allele frequency of the investigated Italian study population is significantly different from the so far investigated German and British study populations.This might be a hint that population-specific factors and/or a different linkage situation with a causative SNP may explain the discrepancy between the two studies. However, as Catucci et al. discussed, also statistical fluctuations might be a quite likely explanation for these observations.Finally, we completely agree with Catucci et al. that large multiplecenter studies are necessary to estimate the effect of this variant on breast cancer risk and clarify possible population specific factors. Hum. Genet., 13, 998-999.
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