A new coupled global NCEP Reanalysis for the period 1979-present is now available, at much higher temporal and spatial resolution, for climate studies. T he first reanalysis at NCEP (all acronyms are defined in the appendix), conducted in the 1990s, resulted in the NCEP-NCAR reanalysis (Kalnay et al. 1996), or R1 for brevity, and ultimately covered many years, from 1948 to the present (Kistler et al. 2001). It is still being executed at NCEP, to the benefit of countless users for monthly, and even daily, updates of the current state of the atmosphere. At the same time, other reanalyses were being conducted, namely, ERA-15 (Gibson et al. 1997) was executed for a more limited period (1979-93) at the ECMWF, COLA conducted a short reanalysis covering the May 1982-November 1983 period (Paolino et al. 1995), and NASA GSFC conducted a reanalysis covering the 1980-94 period (Schubert et al. 1997). The general purpose of conducting reanalyses is to produce multiyear global state-of-the-art gridded representations of atmospheric states, generated by a constant model and a constant data assimilation system. To use the same model and data assimilation over a very long period was the great advance during the 1990s, because gridded datasets available before 1995 had been created in real time by ever-changing models and analysis methods, even by hand analyses prior to about 1965. The hope was that a reanalysis,

The second version of the NCEP Climate Forecast System (CFSv2) was made operational at NCEP in March 2011. This version has upgrades to nearly all aspects of the data assimilation and forecast model components of the system. A coupled reanalysis was made over a 32-yr period , which provided the initial conditions to carry out a comprehensive reforecast over 29 years . This was done to obtain consistent and stable calibrations, as well as skill estimates for the operational subseasonal and seasonal predictions at NCEP with CFSv2. The operational implementation of the full system ensures a continuity of the climate record and provides a valuable up-to-date dataset to study many aspects of predictability on the seasonal and subseasonal scales. Evaluation of the reforecasts show that the CFSv2 increases the length of skillful MJO forecasts from 6 to 17 days (dramatically improving subseasonal forecasts), nearly doubles the skill of seasonal forecasts of 2-m temperatures over the United States, and significantly improves global SST forecasts over its predecessor. The CFSv2 not only provides greatly improved guidance at these time scales but also creates many more products for subseasonal and seasonal forecasting with an extensive set of retrospective forecasts for users to calibrate their forecast products. These retrospective and real-time operational forecasts will be used by a wide community of users in their decision making processes in areas such as water management for rivers and agriculture, transportation, energy use by utilities, wind and other sustainable energy, and seasonal prediction of the hurricane season.

The soil moisture state simulated by a land surface model is a highly modeldependent quantity, meaning that the direct transfer of one model's soil moisture into another can lead to a fundamental, and potentially detrimental, inconsistency. This is first illustrated with two recent examples, one from the National Center for Environmental Prediction (NCEP) involving seasonal precipitation forecasting, and another from the realm of ecological modeling. The issue is then further addressed through a quantitative analysis of soil moisture contents produced as part of a global offline simulation experiment in which a number of land surface models were driven with the same atmospheric forcing fields. These latter comparisons clearly demonstrate, on a global scale, the degree to which model-simulated soil moisture variables differ from each other and that these differences extend beyond those associated with model-specific layer thicknesses or soil texture. The offline comparisons also show, however, that once the climatological statistics of each model's soil moisture variable are accounted for (here, through a simple scaling using the first two moments), the different land models tend to produce very similar information on temporal soil moisture variability in most parts of the world. This common information can perhaps be used as the basis for successful mappings between the soil moisture variables of different land models.-3 -

We review the three genetically determined disorders of glucose transport across cell membranes. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and De Vivo disease (GLUT1 deficiency syndrome (GLUT1DS)) arise from heritable mutations in transporter-encoding genes that impair monosaccharide uptake, which becomes rate-limiting in tissues where the transporters serve as the main glucose carrier systems. We focus in greater detail on De Vivo disease as a prototype of a brain energy failure syndrome, for which the greatest pathophysiological detail is known, but which presents the most therapeutic challenges. The study of these diseases illustrates fundamental aspects of energetic metabolism, while providing the basis for their diagnosis by simple metabolic screening and for their treatment by dietary modification.European Journal of Endocrinology 150 627-633