Metal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the development of novel treatments for lung cancer. This review summarizes examples of anticancer gold(I) and gold (III) complexes for lung cancer treatment, including mechanisms of action and approaches adopted to improve their efficiency. Several excellent examples of gold complexes against lung cancer are highlighted.
Metal-based drugs have been used for decades to treat
solid cancers;
however, these drugs have no significant therapeutic effect on glioma
because they cannot effectively cross the blood–brain barrier
(BBB). To develop a novel metal-based agent that can cross the BBB
to target glioma, we synthesized an Au complex (C2) with remarkable
glioma cytotoxicity and fabricated lactoferrin (LF)-C2 nanoparticles
(LF-C2 NPs) as a novel therapy. We confirmed that C2 kills glioma
cells by inducing apoptosis and autophagic death. The LF-C2 NPs cross
the BBB, inhibit glioma growth, and selectively accumulate in the
tumor tissue, significantly decreasing the side effects of C2. This
study provides a novel strategy for applying metal-based agents to
targeted therapy for glioma.
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