Calcium ions bind at the gating ring which triggers the gating of BK channels. However, the allosteric mechanism by which Ca2+ regulates the gating of BK channels remains obscure. Here, we applied Molecular Dynamics (MD) and Targeted MD to the integrated gating ring of BK channels, and achieved the transition from the closed state to a half-open state. Our date show that the distances of the diagonal subunits increase from 41.0 Å at closed state to 45.7Å or 46.4 Å at a half-open state. It is the rotatory motion and flower-opening like motion of the gating rings which are thought to pull the bundle crossing gate to open ultimately. Compared with the ‘Ca2+ bowl’ at RCK2, the RCK1 Ca2+ sites make more contribution to opening the channel. The allosteric motions of the gating ring are regulated by three group of interactions. The first weakened group is thought to stabilize the close state; the second strengthened group is thought to stabilize the open state; the third group thought to lead AC region forming the CTD pore to coordinated motion, which exquisitely regulates the conformational changes during the opening of BK channels by Ca2+.
The possibility to detect the noncommutative (NC) spacetime in the electric dipole moments (EDM) experiments is studied in the effective field theory of noncommutative Standard Model (NCSM) with many additional deformations. The EDM given by the previous literatures do not have any observable effect since they are spin-independent. In this work, it is found that three of the deformed terms provide extra sources of CP violation contributed to EDM. We show that these EDMs are sensitive to the spin and thus have potential to be measured in the highly precise experiments. In particular, the EDM induced by NC spacetime may not be parallel to the direction of spin, which demonstrates the intrinsic feature of NC field theory.
A two-dimensional numerical modeling has been developed to analyze the dynamic evolution of heat transfer in a cylindrical composite conductor Cu/NbTi . The model solves the transient heat equation coupled with current shift in NbTi and copper. The minimum quench energy and quench propagation velocity are calculated and analyzed, these numerical results yield the experiment results. The effect of different cross-section ratio of copper to superconductor on the electric field produced by heat disturbance is discussed.
The strong coupling constant is an important parameter that can help us understand the strong decay behaviors of baryons. In our previous work, we have analyzed the strong vertices [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] in QCD sum rules. Following these works, we further analyze the strong vertices [Formula: see text] and [Formula: see text] using the three-point QCD sum rules under Dirac structures [Formula: see text] and [Formula: see text]. In this work, we first calculate strong form-factors considering contributions of the perturbative part and the condensate terms [Formula: see text], [Formula: see text] and [Formula: see text]. Then, these form-factors are used to fit into analytical functions. According to these functions, we finally determine the values of the strong coupling constants for these two vertices [Formula: see text] and [Formula: see text].
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