12Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages 13 in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory 14 neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With 15 the use of a transgenic mouse line, optical clearing and imaging techniques, combined with 16 electrophysiological tools, we revealed a population of glycinergic cells in the VCN distinct from 17 the D-stellate cell. These novel multipolar glycinergic cells were smaller in soma size and 18 dendritic area, but over 10-fold more numerous than D-stellate cells. They were activated by 19 auditory nerve fibers and T-stellate cells, and made local inhibitory synaptic contacts on 20 principal cells of the VCN. Given their abundance, combined with their narrow dendritic fields 21 and axonal projections, it is likely that these neurons, here termed L-stellate cells, play a 22 significant role in frequency-specific processing of acoustic signals. 23Axon-dendritic arbors of cell types 132
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.