The high-pace rise in advanced computing and imaging systems has given rise to a new research dimension called computer-aided diagnosis (CAD) system for various biomedical purposes. CAD-based diabetic retinopathy (DR) can be of paramount significance to enable early disease detection and diagnosis decision. Considering the robustness of deep neural networks (DNNs) to solve highly intricate classification problems, in this paper, AlexNet DNN, which functions on the basis of convolutional neural network (CNN), has been applied to enable an optimal DR CAD solution. The DR model applies a multilevel optimization measure that incorporates pre-processing, adaptive-learning-based Gaussian mixture model (GMM)-based concept region segmentation, connected component-analysis-based region of interest (ROI) localization, AlexNet DNN-based highly dimensional feature extraction, principle component analysis (PCA)-and linear discriminant analysis (LDA)-based feature selection, and support-vector-machine-based classification to ensure optimal five-class DR classification. The simulation results with standard KAGGLE fundus datasets reveal that the proposed AlexNet DNN-based DR exhibits a better performance with LDA feature selection, where it exhibits a DR classification accuracy of 97.93% with FC7 features, whereas with PCA, it shows 95.26% accuracy. Comparative analysis with spatial invariant feature transform (SIFT) technique (accuracy-94.40%) based DR feature extraction also confirms that AlexNet DNN-based DR outperforms SIFT-based DR. Keywords Computer-aided diagnosis Á Diabetic retinopathy Á Deep neural network Á AlexNet DNN Á Convolutional neural network Á Gaussian mixture model Á Linear discriminant analysis Á SVM

The recent advancements in Internet of Things (IoT), cloud computing, and Artificial Intelligence (AI) transformed the conventional healthcare system into smart healthcare. By incorporating key technologies such as IoT and AI, medical services can be improved. The convergence of IoT and AI offers different opportunities in healthcare sector. In this view, the current research article presents a new AI and IoT convergence-based disease diagnosis model for smart healthcare system. The major goal of this article is to design a disease diagnosis model for heart disease and diabetes using AI and IoT convergence techniques. The presented model encompasses different stages namely, data acquisition, preprocessing, classification, and parameter tuning. IoT devices such as wearables and sensors permit seamless data collection while AI techniques utilize the data in disease diagnosis. The proposed method uses Crow Search Optimization algorithm-based Cascaded Long Short Term Memory (CSO-CLSTM) model for disease diagnosis. In order to achieve better classification of the medical data, CSO is applied to tune both 'weights' and 'bias' parameters of CLSTM model. Besides, isolation Forest (iForest) technique is employed in this research work to remove the outliers. The application of CSO helps in considerable improvement in the diagnostic outcomes of CLSTM model. The performance of CSO-LSTM model was validated using healthcare data. During the experimentation, the presented CSO-LSTM model accomplished the maximum accuracies of 96.16% and 97.26% in diagnosing heart disease and diabetes respectively. Therefore, the proposed CSO-LSTM model can be employed as an appropriate disease diagnosis tool for smart healthcare systems.

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Clinical Decision Support Systems (CDSS) provide an efficient way to diagnose the presence of diseases such as breast cancer using ultrasound images (USIs). Globally, breast cancer is one of the major causes of increased mortality rates among women. Computer-Aided Diagnosis (CAD) models are widely employed in the detection and classification of tumors in USIs. The CAD systems are designed in such a way that they provide recommendations to help radiologists in diagnosing breast tumors and, furthermore, in disease prognosis. The accuracy of the classification process is decided by the quality of images and the radiologist’s experience. The design of Deep Learning (DL) models is found to be effective in the classification of breast cancer. In the current study, an Ensemble Deep-Learning-Enabled Clinical Decision Support System for Breast Cancer Diagnosis and Classification (EDLCDS-BCDC) technique was developed using USIs. The proposed EDLCDS-BCDC technique was intended to identify the existence of breast cancer using USIs. In this technique, USIs initially undergo pre-processing through two stages, namely wiener filtering and contrast enhancement. Furthermore, Chaotic Krill Herd Algorithm (CKHA) is applied with Kapur’s entropy (KE) for the image segmentation process. In addition, an ensemble of three deep learning models, VGG-16, VGG-19, and SqueezeNet, is used for feature extraction. Finally, Cat Swarm Optimization (CSO) with the Multilayer Perceptron (MLP) model is utilized to classify the images based on whether breast cancer exists or not. A wide range of simulations were carried out on benchmark databases and the extensive results highlight the better outcomes of the proposed EDLCDS-BCDC technique over recent methods.

Complications caused due to diabetes mellitus result in significant microvasculature that eventually causes diabetic retinopathy (DR) that keeps on increasing with time, and eventually causes complete vision loss. Identifying subtle variations in morphological changes in retinal blood vessels, optic disk, exudates, microaneurysms, hemorrhage, etc., is complicated and requires a robust computer-aided diagnosis (CAD) system so as to enable earlier and efficient DR diagnosis practices. In the majority of the existing CAD systems, functional enhancements have been realized time and again to ensure accurate and efficient diagnosis of DR. In this survey paper, a number of existing literature presenting DR CAD systems are discussed and analyzed. Both traditional and varoius evolutionary approaches, including genetic algorithm, particle swarm optimization, ant colony optimization, bee colony optimization, etc., based DR CAD have also been studied and their respective efficiencies have been discussed. Our survey revealed that evolutionary computing methods can play a vital role for optimizing DR-CAD functional components, such as proprocessing by enhancing filters coefficient, segmentation by enriching clustering, feature extraction, feature selection, and dimensional reduction, as well as classification.