Multiparametric MRI accurately identified patients with steatosis, stratifies those with NASH or simple steatosis and reliably excludes clinically significant liver disease with superior negative predictive value (83.3%) to liver stiffness (42.9%) and ELF (57.1%). For the risk stratification of NAFLD, multiparametric MRI was cost effective and, combined with transient elastography, had the lowest cost per correct diagnosis.
BackgroundUse of blood oxygenation level-dependent cardiovascular magnetic resonance (BOLD-CMR) to assess perfusion in the lower limb has been hampered by poor reproducibility and a failure to reliably detect post-revascularization improvements in patients with critical limb ischemia (CLI).ObjectivesThis study sought to develop BOLD-CMR as an objective, reliable clinical tool for measuring calf muscle perfusion in patients with CLI.MethodsThe calf was imaged at 3-T in young healthy control subjects (n = 12), age-matched control subjects (n = 10), and patients with CLI (n = 34). Signal intensity time curves were generated for each muscle group and curve parameters, including signal reduction during ischemia (SRi) and gradient during reactive hyperemia (Grad). BOLD-CMR was used to assess changes in perfusion following revascularization in 12 CLI patients. Muscle biopsies (n = 28), obtained at the level of BOLD-CMR measurement and from healthy proximal muscle of patients undergoing lower limb amputation (n = 3), were analyzed for capillary-fiber ratio.ResultsThere was good interuser and interscan reproducibility for Grad and SRi (all p < 0.0001). The ischemic limb had lower Grad and SRi compared with the contralateral asymptomatic limb, age-matched control subjects, and young control subjects (p < 0.001 for all comparisons). Successful revascularization resulted in improvement in Grad (p < 0.0001) and SRi (p < 0.0005). There was a significant correlation between capillary-fiber ratio (p < 0.01) in muscle biopsies from amputated limbs and Grad measured pre-operatively at the corresponding level.ConclusionsBOLD-CMR showed promise as a reliable tool for assessing perfusion in the lower limb musculature and merits further investigation in a clinical trial.
This paper quantitatively explores, in terms of roughness indices, the effect of soil surface irregularities on the diurnal variation of the broadband blue-sky albedo of a large range of soil properties. Field studies were carried out on cultivated and uncultivated soil surfaces in Poland and Israel that vary in roughness and brightness. It was found that these irregularities, formed by different agricultural equipment and modified by rain or sprinkler irrigation, can be quantified by two roughness indices. Soil roughness not only affects the overall level of the diurnal variation of the albedo, but also affects the intensity of the diurnal increase from the solar zenith angle (µ ) at the local noon to about 75 80 . The roughness indices are variables that precisely determine only the albedo at the local solar noon of soils with the same color value. If the contents of soil organic carbon (SOC) and calcium carbonate are treated as the dominant variables, combined with one of the indices, these three variables together would significantly describe the albedo at the local solar noon of all soil surfaces. The soils, with their high irregularities, showed almost no rising values of albedo at a µ lower than 75 , while the smooth soil surfaces exhibited a gradual increase of the albedo at these angles. It is concluded that the roughness indices provide sufficient means to accurately describe the diurnal variation of the albedo of a wide range of surfaces, disregarding other soil properties.Index Terms-Diurnal albedo variation, field measurements, soil albedo, soils in Poland and Israel, soil surface roughness.
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