To determine whether matrix metalloproteinase (MMP)-9 is a potential mediator involved in the frequently detected blood-brain barrier leakage in human immunodeficiency virus (HIV)-infected patients, zymography was used to detect MMP-9 activity in cerebrospinal fluid (CSF) samples of 80 HIV-infected patients and of 10 control patients. CSF MMP-9 activity was detected in 40% of HIV-infected patients (but not in controls) and was significantly more frequent in HIV-infected patients than in those without neurologic deficits (50% vs. 13.6%). The frequency of CSF MMP-9 activity did not significantly differ between neurologically symptomatic HIV-infected patients with or without opportunistic central nervous system disease (51.6% vs. 48.1%). Additionally, the presence of CSF MMP-9 activity in HIV-infected patients was associated with an increased CSF white blood cell count and an elevated CSF-to-serum albumin ratio, suggesting that it may play a role in blood-brain/CSF barrier leakage in HIV-infected patients.
All species of the genus Alphitobius Stephens, 1829 (Alphitobiini Reitter, 1917, subfamily Tenebrioninae Latreille, 1802) from Africa and adjacent islands are revised. New species: Alphitobius capitaneus
sp. n. from Kenya. New synonyms: Cryptops ulomoides Solier, 1851, syn. n. of Alphitobius diaperinus (Panzer, 1796); Alphitobius rufus Ardoin, 1976, syn. n. of Alphitobius hobohmi Koch, 1953); Peltoides (Micropeltoides) crypticoides Pic, 1916, syn. n. of Peltoides (Micropeltoides) opacus (Gerstaecker, 1871), comb. n. Homonym: Alphitobius ulomoides Koch, 1953 = Alphitobius arnoldi
nom. n. New combinations from Alphitobius: Ulomoides basilewskyi (Ardoin, 1969), comb. n.; Peltoides (Micropeltoides) opacus (Gerstaecker, 1871), comb. n. Figures of all examined species are added and a species key is compiled.
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