Lycopene, a carotenoid rich in tomato fruit (ripe), is an effective antioxidant and free radical scavenger. In this study n-hexane extract of tomato was evaluated for its protective action against oxidative stress in experimental myocardial infarction induced by administration of adrenaline in rats. Adrenaline produced significant elevation of malondialdehyde content of heart, an indicator of lipid peroxidation, with a significant rise in serum aspartate aminotransferase (AST) level and different grades of necrotic changes in myocardium. Rats were treated with two doses of n-hexane extract of tomato, intragastrically daily for one month prior to administration of adrenaline on the 31 st and 32 nd day. Pretreatment of tomato extract (1 mg/kg, 2 mg/kg) and vitamin E (50 mg/kg) significantly reduced the malondialdehyde concentration in heart and significantly lowered the serum AST level in adrenaline treated rats. Myocardial necrosis was significantly prevented by pretreatment. These results suggest that n-hexane extract of tomato possesses antioxidative property that may protect heart against catecholamine induced myocardial infarction.
Miliary tuberculosis is a form of disseminated tuberculosis, which is more frequent in immunocompromised patient. Ocular involvement of mycobacterium tuberculosis is also an uncommon presentation of disseminated tuberculosis. Tubercular uveitis is most frequent form of ocular tuberculosis. If treatment is delayed, it may cause loss of vision. In many case of the systemic TB with ocular involvement, there may be no eye symptoms in early stage. On the other hand, many cases of ocular TB may not have any evidence of systemic TB. Here we have described a case of miliary tuberculosis with ocular uveitis who initially presented with fever without any significant physical findings and later developed eye symptoms including diminished vision. Bangladesh J Child Health 2019; VOL 43 (2) :126-130
Down syndrome is the most common genetic disorder among live born infants, which is associated with a number of congenital malformations and requires a huge medical and social cost. Here, we report a very rare association in an infant with Down syndrome and XY disorder of sex development (DSD). Bangladesh J Child Health 2020; VOL 44 (1) :48-51
Background: Insulin resistance has evolved as an important metabolic alteration in obese children especially during adolescence. Emerging data suggest that insulin resistance in obesity play the key role in the pathogenesis of hypertension, dyslipidemia, impaired glucose tolerance, type 2 diabetes mellitus, non-alcoholic fatty liver disease and metabolic syndrome. Objective: The aim of this study was to assess the insulin resistance status of Bangladeshi obese adolescents in hospital settings. Methods: It was a cross sectional study done in children, aged 10 to 16 years, attending the paediatric endocrine clinic, paediatric outpatient and paediatric inpatient department, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka over a period of 15 months. Homeostasis Model Assessment of Insulin Resistance (HOMA- IR) value was obtained from fasting insulin & fasting blood glucose level to assess insulin resistance in obese and normal weight children. Results: Among obese adolescents, 78.8% were insulin resistant in comparison to16% in non-obese adolescent. Mean HOMA-IR level of obese group were significantly higher than non-obese group (4.46±1.82 Vs 1.98±1.26, p<0.001). Insulin resistance was observed in 73.8% and 84.2% among grade 1 obese and grade 2 obese adolescents respectively. HOMA-IR showed positive correlation with BMI and waist circumference. Insulin resistance showed significant association with central obesity, puberty and acanthosis nigricans (AN). Conclusion: In this study, insulin resistance was observed in higher frequency among obese adolescents than normal weight adolescents. Obese adolescents with central obesity, acanthosis nigricans and puberty are at increased risk of insulin resistance. Bangladesh Med Res Counc Bull 2021; 47(2): 212-218
Mayer -Rokytansky-Kuster- Hauser Syndrome (MRKH) is a rare congenital anomaly, in which derivatives of mullerian duct is partially or completely absent whereas ovaries are normally present in a female patient. The patients usually present to physician with primary amenorrhea in adolescent period, when secondary sexual characteristics develops normally.Surgical correction permits normal sexual function and, possibly, reproduction with assisted techniques in MRKH patients. So,early diagnosis is very important to offer possible treatment options to the parents and patients and also to avoid psychological impact on patient. Here, we have described two cases of MRKH with different presenting complaints. BANGLADESH J CHILD HEALTH 2021; VOL 45 (1) : 48-50
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.