The present study was carried out to evaluate the wound healing potential of the ethanol extract of the whole lajwanti plant on the deep dermal excision wounds in mice. The dried powder of whole plant was sequentially extracted in petroleum ether, chloroform, ethanol and water. Different doses of dried ethanol extract were orally administered in mice for six consecutive days before creation of the rectangular deep dermal excision wound. The wound contraction was recorded daily followed by monitoring the animals for complete healing of wounds. The ability of ethanol extract to influence the collagen, hexosamine, DNA and nitric oxide syntheses and glutathione, catalase, superoxide dismutase and lipid peroxidation was also determined at day7 and 12 post wounding. The administration of 50, 100, 150 and 200 mg/kg body weight of ethanol extract of lajwanti increased the wound contraction in a dose dependent manner accompanied by the reduction in the mean wound healing time which was shortest (18 days) for 200 mg/kg when compared to untreated control (24 days). The ethanol extract of lajawanti increased the synthesis of collagen, hexosamine and DNA and reduced the nitric oxide synthesis on 7 and 12 days post wounding. The glutathione concentration and the activities of catalase, and superoxide dismutase also increased in a dose dependent manner followed by the alleviation of lipid peroxidation. The present study demonstrates that lajwanti enhanced wound healing by increasing the synthesis of collagen, hexosamine, and DNA as well as glutathione concentration and the activities of catalase, and superoxide dismutase enzymes. It also reduced nitric oxide synthesis and lipid peroxidation.
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