Colloidal particles of controlled size are promising building blocks for the self-assembly of functional materials. Here, we systematically study a method to synthesize monodisperse, micrometer-sized spheres from 3-(trimethoxysilyl)propyl methacrylate (TPM) in a benchtop experiment. Their ease of preparation, smoothness, and physical properties provide distinct advantages over other widely employed materials such as silica, polystyrene, and poly(methyl methacrylate). We describe that the spontaneous emulsification of TPM droplets in water is caused by base-catalyzed hydrolysis, self-condensation, and the deprotonation of TPM. By studying the time-dependent size evolution, we find that the droplet size increases without any detectable secondary nucleation. Resulting TPM droplets are polymerized to form solid particles. The particle diameter can be controlled in the range of 0.4 to 2.8 μm by adjusting the volume fraction of added monomer and the pH of the solution. Droplets can be grown to diameters of up to 4 μm by adding TPM monomer after the initial emulsification. Additionally, we characterize various physical parameters of the TPM particles, and we describe methods to incorporate several fluorescent dyes.

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Our objective was to evaluate the association between traditional metrics such as Impact Factor and Eigenfactor with respect to alternative metrics. The Altmetric Attention Score for the top nine pulmonary and critical care journals was compared with Impact Factor, Eigenfactor, and citations over two time periods (2007–2011 and 2012–2016). There was a significant increase in the Altmetric Attention Score (52 from 2007 to 2011 vs 1,061 from 2012 to 2016; p < 0.001) but no significant differences in Total Citations, Impact Factor, or Eigenfactor. There was a strong positive correlation between citations and Altmetric Attention Score, negative correlations between Eigenfactor and Altmetric Attention Score for most journals, and no clear association between Impact Factor and Altmetric Attention Score. Over time, the digital reach of traditional publications has increased significantly, while no significant increase was noted for the traditional metrics. These findings likely reflect discussions of articles online that are not captured by traditional metrics and hence their impact on the community at large.

Systemic mastocytosis (SM) is pathologically characterized by the proliferation of mast cells with infiltrates in various organs, almost always including bone marrow, leading to defects in bone remodeling. Osteoporosis and subsequent fragility fractures are the most common and clinically relevant presentation, although pathologic fracture through the focal lytic lesions can also be observed. Here, we report the case of a 54-year-old woman, with a recent history of unexplained severe allergic reactions, presenting with intertrochanteric fracture of the left femur which on careful history, physical and radiological evaluation was determined to be pathological. The patient was found to have lytic lesions on the CT scan at the fracture site and the pelvis, bilateral femurs, ribs, and sternum, raising suspicion for malignancy. The malignancy workup failed to reveal a primary neoplasm, and the patient was indicated for intramedullary fixation of the left femur along with intraoperative biopsy. Pathologic evaluation of the femoral biopsy was positive for aggregates of mast cells with CD117 (c-KIT, D816V). This finding prompted a bone marrow biopsy, which ultimately led to the diagnosis of aggressive SM. Femoral intramedullary fixation was done with a trochanteric femoral nail, and the patient was postoperatively started on calcium, vitamin D, and physical therapy. Systemic disease was managed by the hematology-oncology team, and the patient was given an epinephrine autoinjector (EpiPen) and managed with midostaurin (Rydapt, Novartis Pharmaceuticals). Treating surgeons should be aware that a pathological long bone fracture can be the initial presentation of SM. Furthermore, surgeons should consider following patients with SM for longer than usual considering a higher risk of complications, such as implant loosening, nonunion, and refracture due to poor and progressively worsening quality of the bone. Our patient was followed with routine visits for 30 months and showed no clinical or radiographical signs of any complications.