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The effects of Murraya koenigii leaves are very less studied in streptozotocin-nicotinamide (STZ-NA) induced diabetes rat model, in spite of several studies reported its antidiabetic effects in alloxan and STZ induced diabetes. The present study was undertaken to assess the effects of Murraya koenigii leaves extract on the blood sugar level (BSL) of STZ-NA diabetic rats. Experimental diabetes was induced by STZ injection intraperitoneally (i. p) after 30 min of NA injection i. p in all groups apart from normal control group. Group I (normal control) and Group II (diabetic control) rats received distilled water. Group III rats treated Metformin, Group IV and Group V rats treated Murraya koenigii aqueous extract and Murraya koenigii methanolic extract respectively. BSL and body weights of rats were measured at each week of the period of 28 days. Our results indicate that oral administration of Murraya koenigii reduces BSL significantly compared with the diabetic group. No weight loss was observed in all groups. The findings of the present study suggest that Murraya koenigii is proven as anti-diabetic agent in diabetic rats.

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Background: Dyslipidemia has been considered as one of coronary risk factors contributing to the cardiovascular diseases. The beneficial effects of Murraya koenigii leaf on HFFD induced hyperlipidemia in rats has been very less reported in the recent review of literature. Aim and Objectives: To study the hypolipidemic activity of Murraya koenigii leaves on the serum lipid profile in HFFD rat model. Material and Methods: Thirty-six rats of either sex were randomly divided into six groups of six animals each. HFFD was fed p.o to all rats from Groups I, II, IV, V and VI except Group III throughout the period of 14 weeks. Group III rats received normal diet and water ad libitum only. Group I, II, IV and V were treated respectively with AEMK (200 mg/kg/day, p. o), MEMK (200 mg/kg/day, p. o), MET (50 mg/kg/day, p. o) and ATO (10 mg/kg/day, p. o). On the last day of experimental study, blood was collected by retro-orbital puncture method. BSL and lipid profile were assessed. Results: Elevated levels of TC, TG, LDL-C, VLDL-C and diminished level of HDL-C were observed in group VI. Murraya koenigii leaves extract exhibited significant hypolipidemic effect on serum TC and LDL-C in rats owing to its hypocholesterolemic properties. AIP was highly significant in both of AEMK and MEMK extracts. Conclusion: Results of the present study have suggested that the antihyperlipidemic activity of Murraya koenigii leaves leading to decrease in serum lipid parameters mainly TC, LDL-C along with atherogenic risk might be due to its presence of bioactive compounds.

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Diabetes is one of the most common metabolic disturbances associated with carbohydrates, lipids, proteins and relative or absolute insulin depletion. Hyperglycemia in type 2 diabetes (T2DM) leads to the increased lipid and decreased total antioxidant capacity followed by development of chronic complications due to oxidative stress. Cumin is one of the medicinal herbs which are being studied for antioxidant, antibacterial and effects. purpose of this study was to evaluate the effect of cumin on status, oxidative stress and antioxidant capacity in patients with T2DM. Two hundred patients with T2DM were selected in the randomized control trial, of which 100 subjects were enrolled as the study group was given 500 mg of cumin powder in capsule form daily along with their drug medication () for 3 months period while 100 subjects on medication of drug () were selected as the control group. Fasting plasma glucose, serum levels of lipid in the form of (MDA) and Total Antioxidant Capacity (TAC) were measured at baseline and also after a period of 3 months intervention period. The result showed a significant reduction in fasting plasma glucose level (FPGL), serum MDA and significant rise in serum TAC in study group by the end of 3 months of cumin supplementation period. Supplement action of cumin leads to improve , antioxidant and decrease oxidative stress in type 2 diabetes patients and could be useful in the management of T2DM.

The demand for innovative solutions has arisen from the inevitability of improved packaging systems to protect processed food from various factors that cause spoilage. Traditional food packaging materials have limitations in fulfilling all the requirements of consumers, such as being inert, cheap, lightweight, easily degradable, reusable, and resistant to physical abuse. Nanofillers incorporated in the polymer matrix can provide potential solutions to these challenges. This review paper deliberates the use of nanofillers in a polymer matrix to develop an active and intelligent polymer nanocomposites-based processed food packaging system. The present review article focuses on the properties of nanofillers and their potential benefits when incorporated into the polymer matrix. It also examines the challenges associated with developing such packaging systems and explores the ways to address them. It highlights the potential of nanofiller-based polymer nanocomposites in developing a novel food packaging system that can improve the shelf-life and quality of processed food. Such systems can protect food from dirt or dust, oxygen, light, moisture, and food-spoiling microorganisms. Incorporating nanofillers can provide a viable solution to these problems. Most importantly, this paper provides research insights into the potential benefits of nanofillers-based polymer nanocomposites and their applications in the food packaging industry. The verdicts of this review will be of interest to the food packaging industry, entrepreneurs and researchers interested in developing sustainable and innovative packaging systems.

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