The
successful rhodium-catalyzed asymmetric hydroformylation and
hydroaminomethylation of α-substituted acrylamides is described
using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone.
A broad scope of chiral aldehydes and amines were afforded in high
yields and excellent enantioselectivities (up to 99%). Furthermore,
the synthetic potential of this method is demonstrated by the single-step
synthesis of the brain imaging molecule RWAY.
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