No abstract

La enfermedad por coronavirus (COVID-19) ha causado un impacto negativo en los procesos de donación de órganos de cadáver en el mundo. La evidencia médica ha sugerido evaluar el riesgo de mortalidad del receptor y riesgo de transmisión del equipo quirúrgico en la decisión de tomar donantes con SARS-CoV-2-positivo. En este caso, nosotros reportamos el proceso de un donante cadavérico de hígado SARS-CoV-2-positivo asintomático para una paciente receptora con falla primaria del hígado trasplantado previamente por trombosis de la arteria hepática catalogada como urgencia de trasplante. El presente caso puede marcar antecedente para que los programas de donación y trasplante comiencen a considerar los donantes SARS-CoV-2-positivo asintomáticos y con alto umbral de ciclo (Ct), para receptores con alta mortalidad y/o morbilidad que potencialmente puedan beneficiarse.

Introduction: Urethral stricture caused by fibrosis is a common medical condition, but topline therapy for this pathology has a high recurrence rate. This study aimed to determine the efficacy of hyaluronic acid (HA) treatment in preventing the development of fibrosis in a rabbit model of urethral anastomosis. Materials and Methods: This experimental study involved 20 rabbits. HA (0.5 mL, 25 μg/ mL) was applied in the experimental group (n = 10) during an experimental urethral anastomosis, and sterile saline (0.9%) solution was applied in the control group (n = 10). Animals underwent reoperation 12 weeks later for urethral resection. Fibrosis, inflammation, and urethral diameter were measured by two blinded pathologists at the site of the anastomosis. Results: The amount of inflammatory infiltrate was similar in both groups. The thicknesses of the collagen fiber band were 275.9 ± 62.3 and 373.4 ± 44.3 μm in the study and control groups (p = 0.001), respectively, and the urethral lumen diameters at the anastomosis site at follow-up were 2575 ± 167 and 2382 ± 214 μm, respectively (p = 0.04). Conclusion: HA treatment reduced fibrosis at the anastomosis site during this experiment; we suggest further research to corroborate its efficacy in the treatment of urethral stricture.