The effects of different solvents and extraction techniques upon the phytochemical profile and anti-Trichophyton activity of extracts from Piper aduncum leaves were evaluated. Extract done by maceration method with ethanol has higher content of sesquiterpenes and antifungal activity. This extract may be useful as an alternative treatment for dermatophytosis.
A convenient method for the preparation of 5-hydroxy-5-trihalo-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones, from the reaction of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones with hydroxylamine and anilines, respectively, using water as solvent and under ultrasound irradiation is reported.
A convenient method to obtain 10 3-amino-5-trifluoromethyl-5-hydroxy-4,5-dihydroisoxazoles and 18 3-amino-5-trifluoromethyl-1H-pyrazoles by cyclocondensation reaction of 4-amino-4-ethoxy-1,1,1,-trifluorobut-3-en-2-ones [CF 3 COCH=C(OEt)NHR, where R = H, Me, Et, CH 2 CH 2 OH, CMe 2 Et, CH 2 Ph, Ph, 4-NH 2 C 6 H 4 , 4-AcC 6 H 4 , 4-NO 2 C 6 H 4 , 5-methylisoxazol-3-yl, thiazol-2-yl, CH 2 CO 2 Et, CH(Ph)CO 2 Me, CH(i-Bu)CO 2 Et] with hydroxylamine, hydrazine and phenylhydrazine is reported.
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