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Rheology of solids is primarily a function of temperature. Mapping depth to the bottom of the magnetic layer (DBML), which is assumed as a proxy for the depth to Curie temperature, can be used to constrain the thermal structure of the lithosphere. Heat flow data are commonly used to address the thermal structure of the lithosphere. However, these data are scarce for the Amazon Craton. Therefore, as an alternative, DBML was calculated using fractal magnetic source distribution. The Amazon craton is usually described in terms of geochronological provinces models. Nevertheless, geophysical data are poorly discussed in these models. We provide a DBML model that was integrated with the potential field, seismic tomography, and crustal thickness data to address this issue. Our model varies from 10 to 80 km, and almost 90% of the estimates are in the 20‐50 km range. The recurrence of long‐wavelength features on independent datasets supports the assessment that the model is robust and recovered real geophysical signals. Our model suggests that the limits between Carajás and Bacajás domains should be revisited as well as the limits between Tapajós and Iriri Xingú domains. Moreover, we also correlate the model with main mineral deposits. Further, the identified DBML anomaly suggests the mantle is serpentinized in the eastern Carajás domain. This feature is highly correlated with high p‐wave velocity indicating fertile mantle conditions, thus making this region favorable for world‐class mineral deposits.