The purpose of this study was to optimize the function of kidneys exposed to I/R injury. Pretreatment as well as posttreatment with Tezosentan successfully decreased Scr, increased GFR, and maintained renal architecture in kidneys after ischemia. Therefore, ET receptor antagonists may be useful to preserve renal function in the transplantation setting.
For the purpose of assessing the consequences of a potential release event from a high-level waste repository, the sorption of ='Am, U7Np, and ?c was measured on two soils as a function of solution concentration of Na and Ca from extremes of weathering intensity areas.Distribution coefficients ( K d values) were determined on subsoil samples from Washington and South Carolina for "'Am, 237Np, and ?c, as a function of equilibrium solution concentration of calcium (Ca") and of sodium (Na'). Kd values decreased in all cases with increasing solution concentrations of (Ca") and (Na'). For the South Carolina subsoil, Kd values ranged from 1.0 to 67 ml/g for ='Am as a function of (Ca"), from 0.2 to 0.002 M, respectively; 1.6 to 280 ml/g for 24'Am as a function of (Na'); 0.43 to 0.66 ml/g for 237Np as a function of (Ca"); and 0.16 to 0.25 ml/g for 237Np as a function of (Na'), from 3.0 to 0.015 M, respectively. For the Washington soil, Kd values were >1200 ml/g for "'Am and ranged from 0.36 to 2.37 ml/g as a function of (Ca") and from 3.10 to 3.90 ml/g for U7Np as a function of (Na'), over the above concentration ranges. Kd values for ?c were essentially zero at all NaHCO, concentrations on the South Carolina subsoil. This study demonstrated that sorption assessments based on plutonium data are inadequate for estimating other actinide elements sorption. "'Am and U7Np were found to be poorly sorbed in comparison to Pu.
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