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This paper evaluates the possible impacts of climate change and land use change and its combined effects on soil loss and net soil loss (erosion and deposition) in the Mae Nam Nan sub-catchment, Thailand. Future climate from two general circulation models (GCMs) and a regional circulation model (RCM) consisting of HadCM3, NCAR CSSM3 and PRECIS RCM ware downscaled using a delta change approach. Cellular Automata/Markov (CA_Markov) model was used to characterize future land use. Soil loss modeling using Revised Universal Soil Loss Equation (RUSLE) and sedimentation modeling in Idrisi software were employed to estimate soil loss and net soil loss under direct impact (climate change), indirect impact (land use change) and full range of impact (climate and land use change) to generate results at a 10 year interval between 2020 and 2040. Results indicate that soil erosion and deposition increase or decrease, depending on which climate and land use scenarios are considered. The potential for climate change to increase soil loss rate, soil erosion and deposition in future periods was established, whereas considerable decreases in erosion are projected when land use is increased from baseline periods. The combined climate and land use change analysis revealed that land use OPEN ACCESSSustainability 2013, 5 3245 planning could be adopted to mitigate soil erosion and deposition in the future, in conjunction with the projected direct impact of climate change.