Patients with ulcerative colitis (UC) and Crohn's disease (CD) are at increased risk for developing colorectal cancer (CRC), and this is believed to be a result of chronic inflammation. Although conclusive evidence is still missing, both epidemiological and experimental observations suggest that certain drugs used to treat inflammation, such as mesalazine, can reduce the incidence of colitis-associated CRC. Therefore, in recent years, several studies have been conducted to dissect the mechanisms by which mesalazine interferes with CRC cell growth and survival. This review summarizes the current information on the molecular mechanisms that underlie the antineoplastic action of mesalazine.
Left anterior accessory pathways are considered to be rare. The junction between the mitral and aortic valves consists of a continuous fibrous tissue. Nevertheless, muscular pathways connecting the left atrial and ventricular myocardium through the fibrous ring between these valves have been observed very rarely. Few reports about successful ablation of left anterior accessory pathways are available. We describe the case of a young patient with episodes of recurrent palpitations due to atrioventricular tachycardia through a manifest left anterior accessory pathway. Complete elimination of the accessory pathway was achieved by means of an ablative procedure via the transaortic retrograde approach.
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