APSE-Aq presents neuroprotective, antioxidant and anti-inflammatory activities. Considering that APSE-Aq is chemically related to salicylic acid, it may act on similar targets.

Ketamine (KET), a NMDA receptor antagonist, has been studied for its rapid and efficacious antidepressant effect, even for the treatment-resistant depression. Although depression is a major cause of disability worldwide, the treatment can be feasible, affordable and cost-effective, decreasing the population health burden. We evaluated the antidepressive-like effects of KET and its actions on monoamine contents (DA and its metabolites, as well as 5-HT) and on tyrosine hydroxylase (TH). In addition DAT and SERT (DA and 5-HT transporters, respectively) were also assessed. Male Swiss mice were divided into Control and KET-treated groups. The animals were acutely treated with KET (2, 5 or 10 mg/kg, i.p.) and subjected to the forced swimming test, for evaluation of the antidepressive-like behavior. Imipramine and fluoxetine were used as references. The results showed that KET decreased dose-dependently the immobility time and shortly after the test, the animals were euthanized for striatal dissections and monoamine determinations. In addition, the brain (striata, hippocampi and prefrontal cortices) was immunohistochemically processed for TH, DAT and SERT. KET at its higher dose increased DA and its metabolites (DOPAC and HVA) and mainly 5-HT contents, in mice striata, effects associated with increases in TH and decreases in DAT immunoreactivities. Furthermore, reductions in SERT immunoreactivities were observed in the striatum and hippocampus. The results indicate that KET antidepressive-like effect probably involves, among other factors, monoaminergic pathways, as suggested by the increased striatal TH immunoreactivity and reduced brain DA (DAT) and 5-HT (SERT) transporters.

Introduction: Multiprofessional support for families that have a child with DM1 seems to be essential, since this chronic condition directly interferes with the family's daily life and requires treatment that requires constant monitoring throughout life. Objectives: To analyze the importance of multidisciplinary and, above all, family support in children with DM1. Methodology: This is an integrative literature review, prepared and conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. The chosen databases were SciELO, LILACS and PubMed and the following descriptors were defined: “diabetes mellitus tipo 1”, “crianças” and “equipe multiprofissional” and their variations and combinations in English. Results and discussion: After the search, 9 articles were selected. According to the results, the multidisciplinary team acts in 3 ways in the care of children and adolescents with DM1: building long-term relationships, integrating knowledge through multidisciplinary teamwork and ensuring adequate documentation. Different professional groups must work as a team in order to provide optimal conditions for high-quality care for these patients. As for family support, it is essential for greater patient autonomy during treatment. Conclusions: The good relationship between the patient's family and the strong performance of a multidisciplinary team present are factors that directly and positively impact the results of the child's exams and their well-being.

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