In our small study, postoperative cardiac index over time was similar in patients with prophylactically administered levosimendan and patients with prophylactically given milrinone. We observed an increase in cardiac output and cardiac index over time in the levosimendan group, whereas cardiac output and cardiac index remained stable in the milrinone group. This pilot study has primarily served to obtain experience using the new drug levosimendan in neonates and infants and to initiate further multicenter trials in pediatric patients.
Our study shows that indirect ophthalmoscopy without specula causes significantly less stress to infants than screening with lid specula and scleral indentation.
Osteopetrosis is a rare but considerable differential diagnose for unclarified change in haematopoetic cell lines combined with severe neurological symptoms mimicking metabolic or haematological disease. Because of this rare disease a consensus protocol for diagnostics, treatment and follow up of patients suffering from osteopetrosis is recently worked out from the European Group of Blood and Marrow Transplantation (EBMT) and the European Society for Immundeficiencies (ESID) to build up a central registry for this disease (available by ansgar.schulz@uniklinik-ulm.de).
The Institute for Vaccine-Safety of the Austrian Green Cross, the so-called "Institut für Impfsicherheit des Osterreichischen Grünen Kreuzes", promoted a postmarketing sentinel study referring to the safety of tick-borne-encephalitis vaccines in spring 2002. Five-hundred selected paediatricians and general practitioners took part and generated data on 25,905 administered doses. They reported on 107/25,907 (0.413 %) local and systemic adverse reactions. The leading side-effect was fever, besides other adverse reactions corresponding to those known in the literature. The age-group most often affected was that of toddlers and infants. Monitoring with the help of selected paediatricians and general practitioners, carried out alongside the routine obligatory procedures of monitoring, proved to be a valid instrument for detecting vaccine adverse events of tick-borne-encephalitis vaccines.
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