An algorithm that employs the back‐off method to provide optimal solutions for integration of design, control, and scheduling for multiproduct systems is presented, featuring a flexibility and feasibility analysis. The algorithm employs Monte Carlo (MC) sampling to generate a large number of random realizations, and simulate the system to determine feasibility. Back‐off terms are determined and incorporated into a new flexibility analysis to approximate the effect of stochastic uncertainty and disturbances. Through successive iterations, the algorithm converges, terminating on a solution that is robust to a specified level of process variability due to stochastic realizations in the disturbances and uncertain parameters. The proposed algorithm has been successfully applied to a multiproduct continuous stirred tank reactor for which optimal design, control, and scheduling decisions are identified, subject to stochastic uncertainty and disturbance. The present approach has been compared to a critical‐set (multiscenario) method showing the benefits and limitations of both approaches. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2379–2389, 2018

 An algorithm for integration of design, control, and scheduling is proposed.  Variable transition times are considered using flexible finite elements.  The proposed algorithm provides a robust solution, superior to the sequential method.  Interactions between design, control, and scheduling are shown to be significant.  Multi-product CSTR case study shows the benefits of the algorithm.

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