Human aortic aneurysms are characterized histologically by an inflammatory infiltrate with severe proteolytic destruction. Rapamycin is an immunosuppressive agent commonly used to control transplant rejection and intimal hyperplasia by modulating the inflammatory cascade. In this experimental model rapamycin suppressed aneurysm expansion, decreased NF kappa B activation (a marker of inflammation), and decreased matrix metalloproteinase-9 levels. It is hoped that rapamycin or other similar anti-inflammatory drugs will one day be able to control aneurysm expansion in patients
This essay advances a deflationary interpretation of populism, Donald Trump and the United States Constitution. It accepts that Trump utilises a populist pose but rejects populism as too reductive for understanding his ascension and constitutional challenge. First, it argues that although he merits the designation, Trump reveals more about populism than populism does about him. Trump illustrates populism's conceptual elasticity but employing it as a frame to understand him imposes coherence upon a figure whose monetised politics are chaotic, shallow and unanchored by principle. Second, populism provides a necessary but insufficient condition for critically explaining Trump's ascension, either in terms of electoral populism or populism in power. Third, while democratic deconsolidation under Trump's presidency cannot be discounted, the Constitution remains resilient in most important respects. A dispassionate constitutional sociology counsels a deflationary understanding rather than an uncritical alarmism that too frequently reproduces and reinforces the darker aspects of Trump's populist political logic.
This article examines some of the hurdles that confront teachers of American government and politics in the United Kingdom. It argues that whilst the problems associated with teaching American politics are hardly unique within the politics discipline, they do pose substantial challenges. In particular, confronting students' stereotypes and prejudices about the United States is a key task of a successful teaching programme. To do this, and to make the study of US politics an ‘active’ one, some suggestions are made as to how the standard ‘textbook approach’ can be supplemented and enhanced.
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