In patients with hereditary angioedema, the prophylactic use of a subcutaneous C1 inhibitor twice weekly significantly reduced the frequency of acute attacks. (Funded by CSL Behring; COMPACT EudraCT number, 2013-000916-10 , and ClinicalTrials.gov number, NCT01912456 .).

Rhinitis is a common chronic condition that has been shown in observational and interventional studies to have a substantial impact on the sufferer. This study was performed to describe the impact of symptoms of allergic rhinitis (AR) on sleep, quality of life, and productivity in a U.S. population. A cohort of AR sufferers and non-AR sufferers was assembled by screening a representative sample of 15,000 households with a self-administered questionnaire in January 2004. A subsample of respondents received a detailed follow-up questionnaire in the May/June pollen season. Of the 7024 individuals with complete data, 3831 met the case definition of AR sufferer; 3193 were non-AR sufferers. Overall, AR sufferers had consistently poorer average scores on the sleep, quality of life, cognition, and productivity scales compared with non-AR sufferers. Subjects with AR symptoms had more sleep impairment (51.2) compared with subjects with non-AR symptoms and those with no symptoms (59.8 and 63.3, respectively). Only 3.6% of subjects with AR symptoms experienced 100% sleep adequacy compared with 11.7% of subjects with non-AR symptoms and 19.2% of subjects with no symptoms. Quality of life and cognition scores were worse in subjects with AR symptoms compared with subjects with non-AR or no symptoms. Work and school productivity was significantly reduced in subjects with AR symptoms in the past 4 weeks compared with subjects with no symptoms (p < 0.05). Individuals who suffer from AR symptoms experience a substantial burden on their ability to sleep, quality of life, cognitive function, and school/workplace productivity.

Mean stool frequency decreased with age as did the variation. This is a combined effect of age and feed type. These data can be used as a guide to the bowel habit of healthy Australian children.

6VM '33IAJ3S X 3JSU3JOJ Xasja' 8EEI-5EEI 4CI jspjosip X)i|puosjod |pposijup SPpiuajqdoziips jo sisou3eipsiLu oq] u suoupjopiMjco |P3iuip 3010$ ippq JOpp^(nt|)~a '.»»ojd-g •¿ $ 'UIAÕ.IJ, 'IIE-80E 'ZÃOEI *nmpfs¿)o pujno[ 4Si]ug-piuajqdoziips q}|M djdoad ui Xji|puosjad pup juaujisnfpp pigjoLuajj (8441) /•> »"V '«A'a "O '«!*»n " '06|-¿8I 'MI 'X •¿ J9pjos|p Xiijpuosjad DJOAOSjo piuajqdoziLps Diuojip qi(M MiMiii-d Suipui^sjopun u; /JiPiipXsd 3|j|iuaost jo 3|OJ SMX'iuaijpd Jiroijjip aqj_ ((,66l) 'M 'p :uopuo-|-¿J-E-dd '(app|s y WipXsj 4)1* MJOIJU,-M;,-»U/ iDjnoiADLiaq-iMiiuSor) u| "sujoidujXs DijoipXsd joj Xdpjoqi jnoiApqaq-aAiiiuSo:> OJ SISOlpXsd ¡O soipnis OAi|iu3o i LUOJJ(964|) •¿ « '||Ejuag

No abstract

No abstract

No abstract

No abstract