In this study, we explore the interesting phenomenon of firing spikes and complex dynamics of Morris-Lecar model. We consider a set of parameters such that the model exhibits a wide range of phenomenons. We investigate the influences of injected current and temperature on the spiking dynamics of Morris-Lecar model. Moreover, we study bifurcations, and computational properties of this neuron model. Also, we define a bound (Max and Min voltage) for membrane potential and a certain voltage value or threshold for firing the spikes. Studying the two co-dimension bifurcations demonstrates much more complicated behaviors for this single neuron model. We also describe the phenomenon of neural bursting, and investigate the dynamics of Morris-Lecar model as a square-wave burster, elliptic burster and parabolic burster.
Pharmacokinetic models are mathematical models which provide insights into the interaction of chemicals with biological processes. During recent decades, these models have become central of attention in industry that caused to do a lot of efforts to make them more accurate. Current work studies the process of drug and nanoparticle (NPs) distribution throughout the body which consists of a system of ordinary differential equations. We use a tri-compartmental model to study the perfusion of NPs in tissues and a six-compartmental model to study drug distribution in different body organs. We have performed global sensitivity analysis by LHS Monte Carlo method using PRCC. We identify the key parameters that contribute most significantly to the absorption and distribution of drugs and NPs in different organs in body.
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