5795In summary, we have demonstrated that cis-[Pt(NH3)2Cl,] reacts with the self-complementary oligonucleotide, [d-(ApGpGpCpCpT)],, to yield a structure with an intrastrand cross-link between two N7 atoms of adjacent guanine residues. Substantial conformational changes accompany this binding. The platinated hexanucleotide does not form a duplex structure.
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