No abstract

Objectives-The aim of this study was to assess the pharmacokinetics and tolerability of Biolimus A9 eluted from Nobori coronary stents.Background-The release kinetics and pharmacokinetics of drugs delivered via coronary stents have been shown to play an essential role in the efficacy and safety of drug eluting stents.

In the patients with first large STEMI intracoronary injection of autologous bone-marrow-derived MNC leads to the significant decrease of myocardial infarction size but not the significant improvement of LVEF after four months. Higher serum LDH levels after STEMI and very large baseline infarction size are predictors of failure of stem cell therapy in our group of STEMI patients.

The safety and efficacy of adenosine pharmacological stress is even better with concomitant exercise. In the light of these benefits we recommend AdenoEX whenever possible.

In this study involving low risk patients, a PCI prior to CABG did not increase morbidity or mortality.