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Assays and mixed culture experiments prove that the supply of chelating substances is frequently the most crucial aspect of phytoplankton nutrition in sea water. Experimental results, theoretical considerations and tentative calculations show that this supply is controlled by the stability of the trace metal chelates and in the sea may be mediated by certain unknown minor components of the dissolved organic matter.The results of Parts I and II are considered together and show how seawater quality is closely related to the chelation of trace metals, mainly iron, and various other factors previously listed in the summary to Part I.

Three patients with chronic graft-versus-host disease (GVHD) developed myasthenia gravis (MG) 762 to 1,180 days after allogeneic bone marrow transplantation. Symptoms of MG were observed after taper or discontinuation of immunosuppressive treatment of chronic GVHD. All patients developed antibodies to acetylcholine receptor, and one had antibody formation to striated muscle. One patient died of complications of treatment of MG. The severity of disease underscores the importance of the differential diagnosis and the need for prompt therapy of this late complication after human bone marrow transplantation.

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