BackgroundThere have been reports and studies indicating audiovestibular disturbances in COVID-19 patients with variations in the percentage of sensorineural hearing loss (SNHL). The purpose of this study is to compare the incidence of newly diagnosed SNHL, sudden idiopathic hearing loss (SIHL), tinnitus, and vestibular disturbances between infected and uninfected patients, as well as to identify population groups at risk.MethodsThis study used TriNetX to obtain statistics on COVID-19 (+) and COVID-19 (−) patients from 61 healthcare organizations. Propensity score with 1:1 matching was used to control confounding variables. This study evaluated the relative risk of developing audiovestibular disturbances up to 1 month after a COVID-19 test and further investigated the incidence in COVID-19 (+) subset groups.ResultsBetween COVID-19 (+) and COVID-19 (−) patients who had an audiogram, there was no statistically significant difference in SNHL or SIHL (SNHL: relative risk [RR] = 0.69, 95% confidence interval [CI] = 0.46–1.04; SIHL: RR = 1.00, 95% CI = 0.42–2.40). Race/ethnicity or specified comorbidity did not affect the incidence of SNHL or SIHL. There was a statistically significant difference in tinnitus and vestibular disturbances between the COVID-19 (+) and the COVID-19 (−) groups (RR = 1.29, 95% CI = 1.01–1.66; RR = 2.33, 95% CI = 2.19–2.48).ConclusionNew onset hearing loss is not more common in patients with a positive COVID-19 test than those with a negative COVID-19 test. Audiologic evaluation is needed to verify reported hearing disturbances. Although statistically significant in specific population groups, tinnitus and vestibular disturbances may not be clinically significant due to the low incidence.
Objective: Otosclerosis, a leading cause of deafness in adults, results from defective bone remodeling of the otic capsule. Bisphosphonates have been used to decrease bone remolding in many diseases, including otosclerosis. This study analyzes whether current literature supports bisphosphonate therapy as an effective treatment for otosclerosis.Design: Scoping review.Methods: A search was performed in three electronic databases; PubMed, Scopus, and Cochrane Control Trials. Articles were screened independently by two masked reviewers based on prespecified inclusion and exclusion criteria. After unmasking, the two reviewers resolved discrepancies through discussion.Results: From the search, 35 unique articles were identified for analysis. The dates of these publications range from 1982 to 2018. Further title and full-text review identified six articles for inclusion in this review. Three of the studies included are randomized controlled trials (RCT)s, and three are retrospective case reviews. These studies analyzed bisphosphonate therapy regimens, but dose and study length varied, making direct comparisons difficult. Only one RCT study was able to show a statistically significant change between patients treated with bisphosphonates compared to a control group. Conclusions:The efficacy of bisphosphonates for halting bone remodeling in otosclerosis remains unclear. Reviewing the literature, we found significant variations in experimental design and few studies of high-level evidence. Future RCTs investigating therapies for otosclerosis are needed before a firm conclusion about bisphosphonates efficacy as a pharmacological treatment of otosclerosis.
HypothesisWith rising deductibles, patients will delay ear surgeries toward the end of the year, and there will be an increase in postoperative complications.BackgroundThe Affordable Care Act (ACA), passed on March 23, 2010, expanded high deductible health plans. The deductible can provide support for patients with high medical costs, but high deductibles deter patients from seeking necessary preventive health care and having elective procedures. Patients may defer care toward the end of the year until the deductible is met. The purpose of this study is to evaluate the relationship between expanding high deductible health plans and the repeal of the ACA's individual mandate on December 22, 2017, with the economic behavior trends of tympanoplasty and mastoidectomy in the fiscal year and surgical outcomes.MethodsTriNetX was used to obtain summary statistics of patients who had tympanoplasty and/or mastoidectomy from 58 health care organizations. TriNetX is a global federated database that contains de-identified patient data from the electronic medical records of participating health care institutions. This study evaluated the trends in ear surgeries from 2005 to 2021 in the fiscal quarters 1 and 4. Relative risk of developing postoperative complications was statistically interrogated.ResultsThe average rate of ear surgeries measured in cases/year was higher in Quarter 4 than in Quarter 1 after the expansion of higher deductible health plans (180; 124; p < 0.0001). After the repeal of the ACA's individual mandate, the rate of ear surgeries in Quarter 4 significantly decreased compared to post-ACA (−3.7; 287; p = 0.0002). No statistically significant differences were notable in postoperative complications.ConclusionsThe expansion of high deductible health plans with a rise in deductibles is associated with an increase in ear surgeries toward the end of the year. The repeal of the ACA's individual mandate is associated with a decreased rate of ear surgeries compared to post-ACA implementation. Despite financial concern, there was no increase in postoperative complications toward the end of the year.
A contemporary, age-specific model for the distribution of burn mortality in children has not been developed for over a decade. Using data from TriNetX, a global federated health research network, and the American Burn Association’s Nation Burn Repository (NBR), we investigated non-survival distributions for paediatric burns in the United States. Paediatric burn patients ages 0-20 between 2010-2020 were identified in TriNetX from 41 Health Care Organizations using ICD-10 codes (T.20-T.30) and identified as lived/died. These were compared to the non-survival data from 90 certified burn centers in NBR database between 2016-2018. The patient population was stratified by age into subgroups of 0-4, 5-9, 10-14, 15-20 years. Overall, mortality rates for paediatric burn patients were found to be .62% in NBR and .52% in TrinetX. Boys had a higher incidence of mortality than girls in both databases (0.34% vs. 0.28% NBR, p = 0.13; 0.31% vs. 0.21% TriNetX, p = <0.001). Comparison of ethnic cohorts between 2010-2015 and 2016-2020 subgroups showed that non-survival rates of African American children increased relative to White children (TriNetX, p = <0.001), however, evidence was insufficient to conclude that African American children die more frequently than other ethnicities (NBR, p=0.054). When analyzing subgroups in TriNetX, burned children ages 5-9 had significantly increased frequency of non-survival, (p = <0.001). However, NBR data suggested that children 0-4 experience the highest frequency of mortality (p = <0.001). The non-survival distributions between these two large databases accurately reflects non-survival rates in burned children.
Introduction Over the past three decades, it has been repeatedly demonstrated that early surgical intervention is associated with improved outcomes in burns, however, large-scale studies regarding the incidence of operative treatment in burn patients are lacking. We conducted a retrospective study using the TriNetX database, a global, real-time electronic medical record driven index of patient populations, analyzing the incidence of grafting procedures in burned patients related to age and % total body surface area (TBSA) burned. Methods The population of burn patients and operative treatments were indexed using ICD-10 codes T31.0-T31.9 and 1013913, respectively. Queries were structured as sequential events allowing analysis of burn diagnosis to be followed by a subsequent operation. The patient population was partitioned by TBSA burned, and the number of grafting procedures were assessed. All patients were included and stratified by ages of 0–17, 18–34, 35–64, and 65–89. The data includes information collected between 2000–2020 from over 35 healthcare organizations comprising the Research network in TriNetX. Extracted data were analyzed using chi-square statistical analysis with p< 0.05 considered significant. Results Of 116,325 burn patients identified, 11.14% underwent at least one grafting procedure. Of surgeries performed, the majority occurred in the 35–64 years age group (45.3% p = < 0.001). Additionally, the incidence of grafting procedures was directly proportional to patient age: age groups of 0–17, 18–34, 35–64, and 65–89 years received grafting procedures in 6.5% (p = < 0.001), 9.8% (p = < 0.001), 12.9% (p = < 0.001), and 15.9% (p = < 0.001) of cases, respectively. When stratified by TBSA burned, those with 40–49% TBSA burns had the highest incidence of operations (50.7% p = < 0.001). Large TBSA burns correlated with increasing incidence of grafting procedures until 50–59% TBSA burned, where incidence begins to decrease, likely related to referral patterns which did not capture grafting procedures performed at specialized burn treatment centers or institution of palliative care. Conclusions This study reveals that the incidence of operational treatment increases with both age and percent TBSA burned. The data corroborate a referral pattern for burns that demonstrates a decline in operative treatments beginning with 50–59% TBSA, inconsistent with referral guidelines to specialized burn care centers published by the ABA.
Introduction:The medical field has incorporated gamification elements into education platforms over the past decade. The standard definition for gamification that has been adopted by most research studies is the addition of game elements and game mechanics within a platform to enhance user engagement. In this review, seven established, consolidated components, as well as an additional new or novel component, will be evaluated: a point system/leaderboards, question banks or gradable content, social interaction with other participants, leaderboards, progress or levels, immediate feedback, badges/icons or a reward system, and the novel component, a story line.Methods: Two reviewers searched MEDLINE, Cochrane, PsycINFO, Web of Knowledge, and the Nursing Registry. This review compares the one identified otolaryngology study with current residency education gamification practices within the medical field.The authors searched "residency AND gamification", "residency AND video games", and "residency AND games". After applying exclusion criteria, the 13 remaining studies included a procedure, questions/scenarios, and at least three gamification elements.Results: Across the 13 studies, the average number of included gamification elements was higher than the minimum threshold of three (3.84). Ten of the studies incorporated leaderboards, feedback, and social interaction; eight incorporated a question bank; and four incorporated progress bars, rewards, and story lines. The otolaryngology study incorporated four of the gamification components: a point system, instant feedback/solution after a question was answered, player-to-player communication, and a leaderboard. Conclusion:Review of the current literature found that the medical field has limited research regarding the use of gamification in educational platforms. Despite many simulation studies and attempts at gamification, the medical community has not fully embraced gamification within residency education. In closing, the medical education community should establish a definition of "gamification" and survey residency programs to identify desired gamification elements.
Introduction A contemporary, age-specific model for the distribution of burn mortality in children has not been developed for over a decade. Using data from both TriNetX, a global federated health research network, and the American Burn Association’s Nation Burn Repository (NBR), we investigated non-survival distributions for paediatric burns in the United States. Methods Paediatric burn patients ages 0–20 between 2010–2020 were identified in TriNetX from 41 Health Care Organisations (HCOs) using ICD-10 codes (T.20-T.30) and identified as lived/died. These were compared to the non-survival data from 90 certified burn centers in NBR database between 2016–2018. The patient population was stratified by age into subgroups of 0–4, 5–9, 10–14, 15–20 years. Descriptive statistics were generated and statistical analysed by chi-square; p < .05 was considered significant. Results 81,507 and 21,442 unique paediatric burn patients were identified in the TriNetX and NBR databases, respectively. Overall non-survival rates were 0.62% and 0.52%, respectively. Boys had a higher incidence of mortality than girls in both databases (0.34% vs. 0.28% NBR, p = 0.13 and 0.31% vs. 0.21% TriNetX, p = < 0.001). When comparing age subgroups in TriNetX, burned children ages 5–9 had significantly increased frequency of non-survival, constituting 65% of all deaths (p = < 0.001). However, NBR data suggested that children 0–4 experience the highest frequency of mortality (p = < 0.001). Comparison of ethnic cohorts between 2010–2015 and 2016–2020 subgroups showed that non-survival rates of African-American children increased relative to white children (TriNetX, p = < 0.001), however evidence was insufficient to conclude that African-American children die more frequently than other ethnicities (NBR, p = 0.054). Conclusions Large sample size databases such as TriNetX and NBR afford sufficient statistical power to reflect relative non-survival rates in burned children. TriNetX also captures a unique demographic of burn patients not treated at ABA certified centers reporting to NBR, informing inferences on results. However, differences in reporting time periods must also be considered. Furthermore, potential ethnic disparities in paediatric non-survival outcomes were identified, meriting further investigation.
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