We consider an in-host model for HIV-1 infection dynamics developed and validated with patient data in earlier work [7]. We revisit the earlier model in light of progress over the last several years in understanding HIV-1 progression in humans. We then consider statistical models to describe the data and use these with residual plots in generalized least squares problems to develop accurate descriptions of the proper weights for the data. We use recent parameter subset selection techniques [5,6] to investigate the impact of estimated parameters on the corresponding selection scores. Bootstrapping and asymptotic theory are compared in the context of confidence intervals for the resulting parameter estimates.

We have explored various different machine learning (ML) approaches for forecasting tsunami amplitudes at a set of forecast points, based on hypothetical short-time observations at one or more observation points. As a case study, we chose an observation point near the entrance of the Strait of Juan de Fuca, and two forecast points in the Salish Sea, one in Discovery Bay and the other in Admiralty Inlet, the waterway leading to southern Puget Sound. One ML approach considered is to train a support vector machine (SVM) to predict the maximum amplitude at the forecast points. We also explored the use of two deep convolutional neural networks, a denoising autoencoder (DAE) and a variational autoencoder (VAE) to predict the full time se-

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