A. W. Brown M. Delbaere P. Eeles S. Johnston R. WeaverCreating service-oriented architecture (SOA) solutions means rethinking the practices currently in use to build systems, reconsidering the skills in an organization, and redefining the ways in which team members collaborate. A service orientation contributes to the development of solutions that are assembled from disparate applications, and SOA is an architectural style that emphasizes loose coupling of independent service providers. This perspective on service orientation is known as service-oriented development of applications (SODA). SODA encompasses composition, adaptive process management, service-based interoperability and integration, discovery and description, and rapid application maintenance. In this paper, we focus on how IBM supports SODA, the relationship of SODA to the IBM Rational Software Development Platform (RSDP), and how IBM's core approach to design and construction-model-driven development-is an essential element in creating effective and efficient services and service-oriented solutions. We explore the concepts behind these approaches and illustrate their realization with illustrative examples from customer experiences.
The results of this study compared favourably with the responses of patients treated with radiation therapy and chemotherapy. The study continues with accrual of additional patients.
Filamentous actin (F-actin) and non-muscle myosin II motors drive cell motility and cell shape changes that guide large scale tissue movements during embryonic morphogenesis. To gain a better understanding of the role of actomyosin in vivo, we have developed a two-dimensional (2D) computational model to study emergent phenomena of dynamic unbranched actomyosin arrays in the cell cortex. These phenomena include actomyosin punctuated contractions, or "actin asters" that form within quiescent F-actin networks. Punctuated contractions involve both formation of high intensity aster-like structures and disassembly of those same structures. Our 2D model allows us to explore the kinematics of filament polarity sorting, segregation of motors, and morphology of F-actin arrays that emerge as the model structure and biophysical properties are varied. Our model demonstrates the complex, emergent feedback between filament reorganization and motor transport that generate as well as disassemble actin asters. Since intracellular actomyosin dynamics are thought to be controlled by localization of scaffold proteins that bind F-actin or their myosin motors we also apply our 2D model to recapitulate in vitro studies that have revealed complex patterns of actomyosin that assemble from patterning filaments and motor complexes with microcontact printing. Although we use a minimal representation of filament, motor, and cross-linker biophysics, our model establishes a framework for investigating the role of other actin binding proteins, how they might alter actomyosin dynamics, and makes predictions that can be tested experimentally within live cells as well as within in vitro models.
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