The inhibition of calculi forming oxalate by dietary Basella rubra plant organs leaf and stem pod has been investigated. The weight reduction assay was studied. Also a concoction of the plant organs was tested. Leaf extract was found with considerable activity whereas the concoction seems to be not much active as the stem pod extract. Soluble oxalate of the plant organs are partially removed prior to extraction of active constituents. The active component/s seem to be a non-protein and non-tannin molecule/s that may act through inhibition of calcium accumulation there by proving the positive activity against the calculi or kidney stone. Regular consumption of leaf and stem pod extracts of our plant would be helpful in calculi prophylaxis.
The main objective of the present investigation was to develop buccal tablets of ramipril, to bypass the first pass metabolism and to improve its oral bioavailability. Ramipril, an ACE inhibitor used in the treatment of hypertension undergoes extensive first pass metabolism and about 25% of the drug reaches the systemic circulation. A unidirectional, bilayered mucoadhesive tablet of ramipril was prepared using HPMC as polymer by direct compression technique. Initially, a backing layer was made by using ethyl cellulose, onto which the drug containing layer as placed and recompressed to get a bilayered tablet. The buccal tablets were evaluated for various parameters such as weight variation test, thickness, hardness, friability, in vitro swelling studies, in vitro mucoadhesion study and in vitro dissolution study. Among the different formulation, the formulation (F1) prepared using 5% HPMC as polymer exhibited satisfactory performance over the other batches and considered as an ideal batch. The release of the drug from the tablets exhibited zero order kinetics and the mechanism of release was governed by diffusion process.
The main aim of the present investigation was to formulate and evaluate gastroretentive floating tablets of theophylline. Theophylline, a brochodialator, used in the treatment of asthma, has good absorption at the gastric pH. Therefore, a floating drug delivery system in a gastric pH could deliver the drug in a slow and sustained manner which could be a useful for broncho dilation in the treatment of asthma. The formulated gastroretentive tablets of theophylline were evaluated for various parameters such as weight variation, hardnesss, friability, drug content, swelling index, buoyancy time and drug release studies. Among the different formulations, formulation F7 prepared using HPMC:Carbopol (1:1 ratio) exhibited better release profile (93.36%) for 8 hours and this batch was selected as an ideal batch. The release of theophylline from the ideal batch was found to follow diffusion mechanism.
The solubility of calcium phosphate crystallization in vitro by an deproteinized concoction of Basella rubra plant was investigated by weight reduction assay. Soluble oxalate of the plant are partially removed prior to extraction of plant material. The weight variation and dissolution results reveals that the concoction showed considerable increased activity at the highest concentration used. The results indicate that the calcium phosphate crystal inhibition activity exhibited by the plant material may be due to their calcium phosphate solubilising capacity of phytoconstituents present in them. Regular consumption of an concoction of our plant would be helpful in calculi prophylaxis.
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