The pancreas is rarely affected by Mycobacterium tuberculosis infections, probably because of the presence of pancreatic enzymes and only few cases are reported. The differential diagnosis with pancreatic carcinoma represents a challenge because of clinical and radiological similarities. We report a case of 30 year-old women presented with pain and lump in epigastric region with constitutional symptoms - weight loss, nausea and occasional vomiting. Preoperative diagnosis of pancreatic tuberculosis requires a high index of suspicion and usually its diagnosis is established after surgical treatment. The diagnosis of this reported case was confirmed by histopathological analysis following laparotomy. The response of the disease to anti tubercular drugs was good.TAJ 2009; 22(1): 264-268
Background: Mosapride, a gastroprokinetic agent that acts as a selective 5HT4 agonist, is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndrome. Non-steroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling. Peptic ulcer is a major side effect of NSAIDs. In this study we tested the effect of oral administration of mosapride 0.25, 0.5, 0.75, 1.25, 2.5 and 5mg/kg on gastric mucosa and on NSAIDs induced gastric ulcers in rats. Methods: Acute gastric ulcers were induced in rats by the oral administration of indomethacin. Results: Mosapride had no effect on gastric mucosa but increased the prostaglandin E2 (PGE2) level. Pretreatment with mosapride at 0.25 and 0.5 mg/kg prevented the mucosal damage induced by indomethacin. The higher doses, from 0.75 up to 5mg/kg, had no effect on indomethacin-induced gastric ulcer. Conclusion: Mosapride had no effect on gastric mucosa but increased PGE2 and demonstrated antiulcer effect in small doses only. This effect could be partially mediated through increased prostaglandin E2.
Tuberculous mastitis is a rare entity in patients with mammary disease even in countries where incidence of tuberculosis is high. In Bangladesh, TB is an endemic disease but breast tuberculosis is rarely reported. Its clinical patterns and treatment strategies are changing day by day. With this study, we aimed to analyze the role of surgery in diagnosis and treatment of hundred (100) cases received care for tuberculous mastitis at the Chest Disease Hospital, Rajshahi, from July’ 2012 to July’ 2016. This is a prospective nonrandomized descriptive study. Diagnosis was made in all patients initially by cytological examination from suspected lesions, which revealed typical tuberculous lesions. In all the patients the diagnosis was confirmed by biopsy of the lesion (open biopsy or core cut biopsy) with histological examination and detection of acid fast bacilli in discharge by Gene x-pert test and Z-N staining to exclude idiopathic granulomatous mastitis, malignancy and very rare concomitant malignancy. Medical therapy with anti-tubercular drugs (ATT) ranging from 9 to 12 months with follow up monthly was the mainstay of treatment. Surgical intervention reserved for selected refractory cases (36%). Extension of anti-tubercular therapy from 9 to 12 or 18 months required in fifty-eight(58) patients on the basis of slow clinical response. Complete resolution obtained in 92 patients but residual tiny mass in eight patients confirmed by repeated FNAC or biopsy to be fibrotic. Surgery play an essential role both in diagnosis and treatment of tubercular mastitis in addition with ATT but beware about unnecessary surgical intervention as majority of patients cured with only ATT.TAJ 2014; 27(1): 44-49
Anorectal disorders include a diverse group of pathological disorders that generate significant patient discomfort and disability. Their prevalence in the general population is probably much higher than that seen in clinical practice, since most patients with symptoms referable to the anorectum do not seek medical attention .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.