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The Fermi surface topology of the shape-memory alloy Ni0.62Al0.38 has been determined using Compton scattering. A large area of this Fermi surface can be made to nest with other areas by translation through a vector of ≈ 0.18 [1, 1, 0](2π/a), which correponds to the wavevector associated with martensitic precursor phenomena such as phonon softening and diffuse streaking in electron diffraction patterns. This observation is compelling evidence that these phenomena are driven by the enhanced electron-lattice coupling due to the Fermi surface nesting.

The existence of flat areas of a Fermi surface (FS), predicted by electronic structure calculations and used in models of both magnetically mediated and phonon-mediated Fulde-Ferrell-LarkinOvchinnikov superconducting states, is reported in the paramagnetic phase of the ferromagnetic superconductor ZrZn 2 using positron annihilation. The strongly mass-renormalized FS sheet, dominating the Fermi level density of states, is seen for the first time. The delocalization of the magnetization is studied using measured and calculated magnetic Compton profiles.

Anti‐transferrin receptor (TfR)‐based bispecific antibodies have shown promise for boosting antibody uptake in the brain. Nevertheless, there are limited data on the molecular properties, including affinity required for successful development of TfR‐based therapeutics. A complex nonmonotonic relationship exists between affinity of the anti‐TfR arm and brain uptake at therapeutically relevant doses. However, the quantitative nature of this relationship and its translatability to humans is heretofore unexplored. Therefore, we developed a mechanistic pharmacokinetic‐pharmacodynamic (PK‐PD) model for bispecific anti‐TfR/BACE1 antibodies that accounts for antibody‐TfR interactions at the blood‐brain barrier (BBB) as well as the pharmacodynamic (PD) effect of anti‐BACE1 arm. The calibrated model correctly predicted the optimal anti‐TfR affinity required to maximize brain exposure of therapeutic antibodies in the cynomolgus monkey and was scaled to predict the optimal affinity of anti‐TfR bispecifics in humans. Thus, this model provides a framework for testing critical translational predictions for anti‐TfR bispecific antibodies, including choice of candidate molecule for clinical development.

Allozyme electrophoresis was used to examine patterns of genetic differentiation in the western minnow, Galaxias occidentalis, from the North Dandalup and Canning Rivers in south-westem Australia. Two distinct genetic forms of this species were identified in these rivers and both forms occur sympatrically in samples from two sites. A significant deficit of heterozygotes and a non-random association of alleles among loci was observed in these two samples. The distribution of one of the genetic forms extended from the headwater streams in the Darling Range to the transition zone between the ranges and the Swan Coastal Plain. With the exception of one population, the distribution of the other form extended from the transition zone to the Swan Coastal Plain. The exception was a population that was caught from a site in the ranges but grouped with the populations from the coastal plain. Discriminant analyses of meristic and morphological data were undertaken to determine if morphological differences exist between the two identified genetic groups. All individuals were correctly classified by the analyses of samples from each catchment separately and of the two sympatric populations separately. However, the discriminant analysis of individuals from all sites correctly classified only 85.7% of the Darling Range genetic group and 79.4% of the Swan Coastal Plain genetic group. Further research is required to clarify the taxonomic status of these two genetic forms of G. occidentalis.

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