A759(6±3 weeks after V1), final visit (12±3 weeks after V1). HRU data are collected via validated patient questionnaires and clinical charts. Student's T-test (continuous variables), chi-square test or Fisher's exact test (categorical variables) were used for group comparisons. Results: At data cut-off (29 May 2017), 123 patients were eligible: CNS metastases cohort n= 49 and non-CNS metastases cohort n= 74. Baseline characteristics were similar between cohorts: mean age 63 vs 67 years; 53% vs 66% male; mean BMI 23.6 vs 24.9 kg/m2; ex-smoker status 51% vs 47%; mean time since diagnosis 6.1 vs 5.4 months; ECOG PS 1 55% vs 54%, and 1-2 chronic comorbidities 51% vs 49%. At V1, 41% (CNS metastases cohort) and 14% (non-CNS metastases cohort) had ≥ 3 metastatic sites (p= 0.002). Dyspnoea (16% vs 31%, p= 0.07), cough (14% vs 28%, p= 0.07) and pain (12% vs 28%, p= 0.03) were more common in the non-CNS metastases cohort. Similar HRU patterns were recorded in the cohorts before V1; no significant differences in number of hospitalizations (p= 0.75), emergency room (p= 0.22) or outpatient visits (p= 0.22). Length of hospital stay was significantly longer in the CNS metastases cohort (p< 0.001). ConClusions: Interim data from a small sample suggest that the CNS and non-CNS metastases cohorts have similar HRU, except length of hospital stay. Final analyses including the full patient cohort will help understand the economic impact of this difference.
Background and Aims:High comorbidity between severe mental disorders and substance dependence has been observed in our area. Dual pathology oriented programs are crucial in developing treatment strategies for these patients. This study describes the profile of the patients admitted in our dual pathology unit so as to evaluate and plan more efficient and effective treatments.Methodology:Correlative admitted patients have been included in the period between January 2005 and July 2005(N=50). Sociodemographical data, medical and psychiatric history, substance abuse pattern and treatments received have been collected.Results:Although the heterogeneity of the studied sample, the most frequent profile observed has been low social class, Mediterranean male stereotype affected of schizophrenia and related disorders or with borderline personality disorder. Cannabis and alcohol are the most frequent substances.Conclusions:the results of this study contributes to elaborate and modify our dual pathology program.
A379tion occurred among 36% and 50% of P-PGI2 and NP-PGI2 patients, respectively; mean (SD) weeks to augmentation were 7 (15) and 3 (8). ConClusions: Use of other PAH therapies prior to PGI2 is common, particularly among NP-PGI2. Our findings suggest that parenteral PGI2 may be reserved for more severe PAH patients.
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