Latent tuberculosis infection (LTI) is an obstacle in eradicating pulmonary tuberculosis. 5-10% people with LTI will develop into active tuberculosis (TB) in the first 5 years after the first TB infection. Islamic boarding schools are a highly potential area in increasing LTI incidents in adolescents. Existing studies are mostly focused on reporting LTI in the general population. To determine the prevalence and risk factors of LTI in adolescents in islamic boarding schools in Bangkalan Madura. A cross sectional study was conducted at the Islamic Boarding School Bangkalan Madura in January 2022 using a random sampling technique. The IGRA examination using the QIAreach QuantiFERON TB tool. The risk factors analyzed include age, gender, nutritional status, TB contact history, duration of stay in Islamic boarding schools and level of knowledge. The data obtained were further analyzed using chi-square and logistic regression test. A total of 100 subjects were examined by IGRA resulting in 30 positive subjects consisting of 30.3% male and 29.9% female. TB contact history (OR 5.167; 95% CI = 1.831-14.567; p=0.002) and level of knowledge about TB (OR 0.019; 95% CI = 0.005-0.069; p<0.05) are significantly related to the incidence of LTI in adolescents in islamic boarding schools.
Hyperbilirubinemia is one of the most common clinical phenomena found in newborns, which is about 60% of term infants and 80% of preterm infants in the first week of life. Severe hyperbilirubinemia can cause encephalopathy and permanent neurodevelopmental damage with an incidence that varies between 4% - 60.3% and mortality rate of 13% to 56.8% worldwide. Phototherapy and exchange transfusion are therapeutic modalities for infants with severe hyperbilirubinemia. Intensive phototherapy has fewer side effects and can reduce the need for exchange transfusion. This treatment is rarely needed if intensive phototherapy is effective, current guidelines for the management of hyperbilirubinemia focus on the use of intensive phototherapy as initial treatment. This literature review aims to discuss intensive phototherapy as the initial management of severe hyperbilirubinemia in neonates.
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