DNA endonuclease CtIP is involved in both DNA double-strand break (DSB) repair and transcriptional repression/activation. The cyclin-dependent kinase inhibitor P21, which is induced at transcription level in response to a variety of stresses, controls G1/S transition. In this report, we found that CtIP bound to the P21 promoter, and this binding was enhanced in response to DNA damage. Concomitantly, ectopic expression of CtIP increased P21 promoter activity, and this increment was enhanced upon camptothecin treatment. Conversely, DNA damage failed to induce P21 gene expression in CtIP-deficient cells. Taken together, our data demonstrate that CtIP is required for DNA damage-induced P21 induction.
In-chain functionalized syndiotactic 1,2-polybutadiene through copolymerization of 1,3-butadiene and 1-substituted 1,3-diene comonomer by a Ziegler–Natta iron(iii) catalytic system.
Correction for ‘In-chain functionalized syndiotactic 1,2-polybutadiene by a Ziegler–Natta iron(iii) catalytic system’ by Shanshan Liang et al., RSC Adv., 2019, 9, 33465–33471, DOI: 10.1039/C9RA06499K.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.