Two principal toxins of diarrhetic shellfish poisoning, okadaic acid and dinophysistoxin-1, were esterified with 9-anthryldiazomethane in methanol. After cleaning with a Sep-pak silica cartridge column, the fluorescent esters were analyzed on a Develosil ODScolumn with MeCN-MeOH-H2O (8 : 1 : 1). The fluorescence intensities of both toxin derivatives measuredat an excitation of 365nmand an emission of 412nmshowed good linearity in the range 1~80ng.
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