Wine production is an important socio-economic activity in Mediterranean countries. This study is focused on wine production under warm and dry climate conditions in south Portugal, in two major wine-producing regions (Tejo and Alentejo), characterized by small to medium sized wineries. Vineyards have been expanding in this region of Portugal, where about 50–70% of the vineyards are irrigated, increasing regional water demand. The aim of this study is to propose an integrative approach for wine production, where a simple calculation model has been developed and validated to preview water consumption and wastewater production, as functions of winemaking periods and type of processed grapes. Results revealed a global ratio of 2.2 ± 0.45 and 2.1 ± 0.17 Lwater/Lwine. Concerning dedicated indicators, 60–75% of the wastewater was produced during Period I and the red wine production represented a 50–64% increase in water consumption. This tool will enable winemakers to calculate Global and Dedicated Indicators, based on their own parameters, which provide information on flow volumes and peak flows. In this context, it will be possible to identify improvements for wastewater treatment and management towards water reuse as a promising solution for the wine sector in the framework of the circular economy.
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