The Journal of International Advanced Otology (J Int Adv Otol) is an international, peer reviewed, open access publication that is fully sponsored and owned by the European Academy of Otology and Neurotology and the Politzer Society. The journal is published triannually in April, August, and December and its publication language is English. The scope of the Journal is limited with otology, neurotology, audiology (excluding linguistics) and skull base medicine. The Journal of International Advanced Otology aims to publish manuscripts at the highest clinical and scientific level. J Int Adv Otol publishes original articles in the form of clinical and basic research, review articles, short reports and a limited number of case reports. Controversial patient discussions, communications on emerging technology, and historical issues will also be considered for publication. Target audience of J Int Adv Otol includes physicians and academics who work in the fields of otology, neurotology, audiology and skull base medicine.
Purpose: To describe a rare presentation of a case of intraocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. Case description: A 9-year-old male child with previous history of ciliary body non-teratoid medulloepithelioma presented with a swelling in the right pre-auricular region for 1 month. Magnetic resonance imaging and positron emission tomography–computed tomography showed a right intraparotid mass with enlarged ipsilateral cervical lymph nodes. A core biopsy was taken from the lesion, which on microscopy showed a tumor composed of small round cells arranged in cords, tubules lined by multilayered cells, and in cribriform pattern. These cells were embedded in a hypocellular, loose myxoid matrix. Based on the histopathological characteristics and previous history, a diagnosis of medulloepithelioma metastastic to ipsilateral parotid gland was made. The patient underwent right total conservative parotidectomy and bilateral neck dissection. Histopathological examination revealed metastatic medulloepithelioma in five out of eight intraparotid lymph nodes, with extranodal extension into the adjacent parotid parenchyma. Foci of hyaline cartilage were identified within the tumor, leading to a diagnosis of metastatic teratoid medulloepithelioma. Conclusion: Intraparotid lymph node metastases from intraocular medulloepithelioma is a rare possibility and we recommend that the parotid should be evaluated in cases of intraocular medulloepithelioma at initial presentation as well as during the follow-up period. Also, metastasis should be considered in all pediatric patients with solitary mass lesions showing unconventional histology for a primary parotid neoplasm.
Introduction: Thyroid swelling is one of the most common disease presenting to otorhinolaryngology out patient. Fine needle aspiration cytology is key point in planning the surgical management. The discrepancy between cytology and histology reported in wide range depending upon centres. We planned to conduct this study with aim of knowing the sensitivity of cytology which can guide the need of surgical or observational treatment. Methods: Our study is prospective enrolling the patients with thyroid swelling who underwent surgical treatment between 1st October 2020 to 11th November 2021. Clinical, cytological and histological parameters were recorded. Accounting histology as gold standard, sensitivity, specificity and accuracy of fine needle cytology were calculated. The correlation was evaluated by chi square test. The p value of ≤0.05 was considered significant. Results: The most common age group reporting was 20-40 years accounting for 68.6% of cases with the female predominance (92.2%). The accuracy of fine needle cytology in detecting non neoplastic, neoplastic benign and neoplastic malignant lesion were 96.0%, 96.0% and 100.0 % respectively. Conclusions: Fine needle cytology is good tool for deciding surgical management for thyroid nodule and recommended for all cases.
The interrenal tissue of the air-breathing fish, Heteropneustes fossilis, became hypertrophied during the breeding period. The interrenal cell cytoplasm became acidophilic and vacuolated, cytoplasmic granulation disappeared and the cell nuclei increased in size. The diameter of the nuclei varied from 2\m=.\07 to 3\m=.\12\g=m\m in the non-breeding period while in the breeding season there was almost uniform enlargement (4\m=.\54 \ m=+-\0\m=.\36 \g=m\m). Variation in nuclear size was most pronounced during maturation of the gonads, i.e. in April. However, the size of larger nuclei (average diameter 6\m=.\53\ m=+-\ 0\m=.\98 \g=m\m) was not significantly different from that of thesmaller nuclei (average diameter 4\m=.\61 \ m=+-\ 0\m=.\61 \g=m\m)during this period (P > 0\m=.\05).The volume density of the cell components of the interrenal tissue nearly doubled in the breeding period but the relative proportions remained more or less the same. Glycogen granules, which appeared to be uniformly distributed in the interrenal cells in the non-breeding period, became aggregated and clumped in many parts of the cell during the breeding period. There was a clear increase in the chromaffin reaction in the chromaffin cells during the breeding period but the iodate reaction, indicating noradrenaline content, decreased considerably.In the ovarian cycle there was a close relationship between gonadosomatic index, ova diameter and water temperature. There was a more than tenfold increase in the gonadosomatic index in the breeding period (1\m=.\30 in the non-breeding and 15\m=.\27in the breeding periods). In males, the rise in the gonadosomatic index in the breeding period corresponded to that of the ovary in degree (0\m=.\22 in the non-breeding and 3\m=.\20 in the breeding periods). In the non-breeding period the thyroid follicles were composed of squamous epithelium (epithelial height 1\m=.\2\p=n-\2\m=.\2 \g=m\m) with a follicular diameter of 48\p=n-\76 \g=m\m and the colloid completely filling the lumina of the follicles; features indicative of hypofunction of the gland. In the breedinĝ period, the follicles were composed of cuboidal epithelium (epithelial height nearly three times that in the preceding period, 4\ m=. \ 1\ p=n-\ 6\ m=. \ 3 \g=m\m) follicular diameter was reduced (36\p=n-\48 \g=m\m) and the colloid incompletely filled the lumina, thus suggesting normal or slight hyperfunction of the gland.
received chemotherapy only (68.3%). We observed a statistically significant difference between the two modalities in white patients, patients aged between 40 to 59 years, tumors arising in sigmoid colon or rectum, patients with elevated CEA levels, and those with metastasis to the lungs only or both lung and liver. Conclusions: Combining pulmonary metastasectomy with chemotherapy in CRC patients with pulmonary and extrapulmonary metastases shows higher 1-year relative survival rates when compared to using chemotherapy alone. Legal entity responsible for the study: Inas Uthman Funding: Has not received any funding Disclosure: All authors have declared no conflicts of interest.
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