Coenzyme Q10 is a compound that functions as an antioxidant with a large molecular weight of 863.36 g/mol and has lipophilic properties. This makes coenzyme Q10 need to be formulated to improve the solubility of the material and the delivery system in the skin. This study aims to determine the effect of surfactant variations (a combination of PEG-40 HCO and Span 80) on the physical characteristics of nanoemulsion and nanoemulsion gel preparations. Coenzyme Q10 is formulated using the rice bran oil oil phase with the combination surfactant. This research was made in 3 nanoemulsion formulas FI, F2, F3 and 3 nanoemulsion gel formulas F4, F5, F6. Evaluation of physical characteristics is done after 24 hours after the preparation is complete, observations made include organoleptic (shape, color and phase formed), pH, viscosity, droplet size, zeta potential and polydispersity index. The research data were processed statistically using the Kruskal-Wallis analysis and Mann-Whitney follow-up tests. The results showed that the surfactant concentration affected physical characteristics (viscosity, droplet size, zeta potential and polydispersity index) with a significantly different result (p <0.05) but the surfactant concentration did not affect the pH with the results not significantly different (p> 0.05)
In this study, the HPLC and Total Organic Carbon (TOC) analysis methods have been developed and validated for the determination of the amount of Mometasone furoate and CIPioo residues on the surface of production equipment and to confirm the efficiency of the cleaning procedure. Mometasone furoate and CIPioo have been chosen based on the worst case assessment approach. The limit of mometasone furoate contamination that has been determined is 100 ug/swab and the specified limit of CIPioo contamination is 100 ug/swab which should not be exceeded during sequential cleaning of the equipment. Mometasone furoate shows good linearity in the range 0.1-1.0 ppm for the HPLC method and CIPioo 2.0-10.0 ppm for TOC Analysis. The percentage of recovery from stainless steel plates using swab sampling techniques was found in the limits of 95.12% and 99.93% respectively in the HPLC and TOC methods. Both methods are simple, inexpensive, short analysis time and high sensitivity for quantitative determination of Mometasone furoate and CIPioo on the surface of manufacturing equipment well below the contamination limit. The validated method meets the requirements for demonstration of the validation of residual cleaning of mometasone furoate and CIPioo on the surface of production equipment
Penelitian ini bertujuan untuk mengetahui pengaruh variasi komposisi alfa arbutin dengan hidroksipropilbeta siklodekstrin (HPBCD) yang dibentuk kompleks inklusi dengan menggunakan metode kneading,dibandingkan campuran fisiknya terhadap karakteristik dan stabilitasnya, yang disimpan pada suhu40o±2oC dan kelembaban 75%±5% selama 30 hari. Variasi komposisi molar alfa arbutin : HPBCD pada campuran fisik yaitu 1:1 (F1), 2:1 (F2), dan 1:2 (F3), sedangkan pada komplek inklusinya adalah 1:1 (F4), 2:1 (F5),dan 1:2 (F6). Interaksi padatan yang terbentuk pada komplek inklusi dan campuran fisik dikarakterisasi denganmorfologi, gugus fungsi, titik lebur, kadar alfa arbutin dan hidrokinon sebagai hasil urainya, serta uji disolusi.Berdasarkan hasil penelitian dapat disimpulkan bahwa telah terjadi pembentukan komplek inklusi antara alfaarbutin dengan HPBCD yang dibuat dengan metode kneading. Hasil pembentukan komplek inklusi yang palingbaik secara berurutan adalah pada F6, F4, dan F5, karena memberikan perbedaan karakteristik fisikokimiasecara bermakna. Komplek inklusi menunjukkan kristal amorf yang lebih homogen, kadar alfa arbutin yanglebih tinggi dan stabil (48,32 ± 0,10%), serta laju disolusi yang lebih cepat dengan persen terdisolusi palingtinggi dibanding formula lainnya. Tidak terjadi perubahan fisikokimia baik pada campuran fisik maupun komplek inklusinya, dan hidrokinon yang merupakan hasil urai alfa arbutin tidak terbentuk selama dilakukan ujistabilitas dipercepat.
Printing: PT ISFI Penerbitan Updating Information on the Field of Pharmaceutical Sciences : M.dlo Phama.eutica lhdon.siono a Vol-1 Na-1 a Juni 2Ot 6 t I Published by Faculty of Pharmacy, University of Surabaya Media Pharmaceutica Indonesiana (MPI) publishes papers (in Bahasa Indonesia and Englishl reporting the results of original research, short communications and critical reviews on all pharmaceutical fields. It covers a wide range of pharmaceutical biology, pharmaceutical chemistry, pharmaceutics, pharmacology and toxicolory, community and clinical pharmacy, pharmaceutical microbiology as well as other researches related to the pharmaceutical issues.
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