Sustainability is the ability to nurture or support a process for an extended period without compromising the needs of the future generation. Sustainable chemistry is a term that refers to the creation of chemical products and processes that decreases or remove the use and production of hazardous substances. Even though sustainable and green technologies have evolved in other scientific fields, their use in the pharmaceutical industry is still initial stage. Therefore, we need to work in green chemistry to ensure its growth in the pharmaceutical industry. Thus, the current review aimed to highlight the need for green chemistry or sustainable chemistry and its principles and its application in the pharmaceutical industry to practice environment-friendly production of pharmaceutical products and reduce or stop the production of harmful intermediates and products during the synthesis process.
Over the past few years, research and progress in 3D printing have become evident. The process of bioprinting involves the use of a bioink composed of human cells or tissue. For example, 3D printing in organ transplantation aims to develop an organ that can synchronize with other physiologic components. In the past ten years, bioprinting has made a substantial leap. It has been used in the fabrication of living tissues for its application in various areas. Moreover, this technology has also been commercialized, resulting in its significant interest from the research fraternity. Thus, this review provides a brief on the development of the field from its foundation to the current commercialization with respect to the polymer Gelatin Methacrylate.
Keywords: 3D Bioprinting, Stem cells, GelMA, Regenerative Medicine
Introduction: Pharmacovigilance (PV) is defined as the science and activities related to the detection, assessment, understanding, and prevention of Adverse Drug Reactions (ADRs) and related conditions.
Methods: In the 1970s, several significant cases of ADR aided the advancement of the discipline. Between 1989 and 2004, several attempts were made to implement such a program in India, but the scheme was eventually launched in 2010 and is now operating successfully and producing positive results.
Results: The pharmacovigilance Program of India (PvPI) contributed different data to the World Health Organization (WHO) Uppsala Monitoring Center (UMC) based on the data gathered from this process. Indian regulatory have sent several alerts to stakeholders and provided the Central Drugs Standard Control Organization (CDSCO) with several recommendations. CDSCO has since advised Marketing Authorisation Holders (MAHs) to follow the same guidelines and has amended the Drugs and Cosmetics Act and Regulations to reflect this.
Conclusions: The time has come for Indian regulatory authorities to take the required action based on data generated in our country rather than data generated in several other countries.
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