The objective was to develop evidence -based recommendations and a research and educational agenda for the non-pharmacological management of hip and knee osteoarthritis (OA). The multidisciplinary task force comprised 21 experts: nurses, occupational therapists, physiotherapists, rheumatologists, orthopaedic surgeons, general practitioner, psychologist, dietician, clinical epidemiologist and patient representatives. After a preliminary literature review, a first task force meeting and five Delphi rounds, provisional recommendations were formulated in order to perform a systematic review.

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In this article, we describe the translation and validation of the Dutch Big Five Inventory (BFI; John & Srivastava, 1999), a short instrument designed to measure the Big Five factors of personality. We obtained evidence of the instrument's good psychometric properties in terms of factorial equivalence to the English original and other BFI translations and the relative independence and internal consistency of the five scales. The findings suggest that the instrument can be used in diverse age groups without substantial changes in factor structure. The Dutch BFI scales showed similar demographic correlates as the English original, with higher Agreeableness and Conscientiousness and lower Neuroticism values in older participants, higher Neuroticism values in women, and higher Openness and Conscientiousness values in better educated participants. Use of the Dutch BFI will allow researchers to integrate their findings with the extant Big Five research literature. The brevity of the instrument will be appealing to researchers who are concerned about taxing the time and motivation of their participants.

There is convincing evidence for the known and unambiguously accepted beneficial effects of glucocorticoids at low dosages. However, the implementation of existing recommendations and guidelines on the management of glucocorticoid therapy in rheumatic diseases is lagging behind. As a first step to improve implementation, we aimed at defining conditions under which long-term glucocorticoid therapy may have an acceptably low level of harm. A multidisciplinary European League Against Rheumatism task force group of experts including patients with rheumatic diseases was assembled. After a systematic literature search, breakout groups critically reviewed the evidence on the four most worrisome adverse effects of glucocorticoid therapy (osteoporosis, hyperglycaemia/diabetes mellitus, cardiovascular diseases and infections) and presented their results to the other group members following a structured questionnaire for final discussion and consensus finding. Robust evidence on the risk of harm of long-term glucocorticoid therapy was often lacking since relevant study results were often either missing, contradictory or carried a high risk of bias. The group agreed that the risk of harm is low for the majority of patients at long-term dosages of ≤5 mg prednisone equivalent per day, whereas at dosages of>10 mg/day the risk of harm is elevated. At dosages between >5 and ≤10 mg/day, patient-specific characteristics (protective and risk factors) determine the risk of harm. The level of harm of glucocorticoids depends on both dose and patient-specific parameters. General and glucocorticoid-associated risk factors and protective factors such as a healthy lifestyle should be taken into account when evaluating the actual and future risk.

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Background: This meta-analysis examined differences in health-related quality of life (HRQoL) between seekers of surgical and non-surgical treatment, and non-treatment seekers, over and above differences that are explained by weight, age, and gender.Methods: Our literature search focused on the 'Impact of Weight on Quality of Life-Lite' (IWQOL-Lite) and the 'Short Form-36' (SF-36) questionnaires. Included were studies published between 1980 and April 2006 providing pre-treatment descriptive statistics of adult overweight, obese or morbidly obese persons. Excluded were elderly and ill patient groups.Results: 54 articles, with a total number of nearly 100,000 participants, met the inclusion criteria. Persons seeking surgical treatment demonstrated the most severely reduced HRQoL. IWQOL-Lite scores showed larger differences between populations than SF-36 scores. After adjustment for weight, the population differences on the IWQOL disappeared. In contrast, the differences on the SF-36 between the surgical treatment seeking population and the other populations were maintained after adjustment for weight.Conclusion: The IWQOL-Lite questionnaire predominantly reflects weight-related HRQoL, whereas the SF-36 mostly reflects generic HRQoL that is determined by both weight and other factors. Our metaanalysis provides reference values that are useful when explaining or evaluating obesity-specific (IWQOL-Lite) or generic (SF-36) HRQoL, weight, and demographic characteristics of obese persons seeking or not seeking surgical or non-surgical treatment.Key words: Obesity, morbid obesity, body mass index, weight loss, quality of life, SF-36, IWQOL-Lite, bariatric surgery, diet therapy, meta-analysis IntroductionAn increasing number of people are facing the burden of obesity, which is defined as a body mass index (BMI) of ≥30 kg/m 2 .1,2 This worldwide epidemic is a concern to health professionals, because obesity is closely linked to risk factors associated with impaired health, shortened life expectancy, 3 and reduced health-related quality of life (HRQoL).4 Our meta-analysis focuses on the impact of obesity on HRQoL. HRQoL is of relevance as an outcome measure in obesity, when treatment options are evaluated in terms of risks and benefits with regard to the health, well-being, and general functioning of the patient. HRQoL may differ among subgroups of obese persons, who seek surgical or non-surgical treatment, or who do not seek treatment for their overweight. Some studies demonstrated greater impairment of HRQoL in people seeking treatment, especially treatment of greater intensity. [5][6][7][8] The quantification of HRQoL in obese people seeking and not seeking treatment will indicate whether over and above other possible factors such as weight, age, and gender, the HRQoL differs among persons who seek a specific kind of treatment for obesity. In addition, such a quantification will provide reference data that are useful when evaluating the baseline status of obese individuals who apply for weight-reducing interventions.The ...

Our results suggest that eating behavior improves both short- and long-term after surgery for severe obesity. Although LAGB could be a long-term solution to part of preoperatively eating disordered patients, the identification and treatment of postoperative binge eating appear critical to promote successful outcome after bariatric surgery.

To develop and validate an ultra‐short measure to assess the Big Five in social network designs, the unipolar items of the Ten‐Item Personality Inventory were adapted to create a bipolar single‐item scale (TIPI‐r), including a new Openness item. Reliability was examined in terms of the internal consistency and test–retest stability of self‐ratings and peer‐rating composites (trait reputations). Validity was examined by means of convergence between TIPI‐r and Big Five Inventory (BFI) scores, self‐peer agreement and projection (intra‐ individual correlation between self‐ and peer‐ratings). The psychometric quality of the TIPI‐r differed somewhat between scales and the different reliability and validity criteria. The high reliability of the peer‐rating composites motivates to use the TIPI‐r in future studies employing social network designs. Copyright © 2007 John Wiley & Sons, Ltd.