Previously reported work has shown that a reduction in the rate oftritium-labelled actinomycin D ([3H]AMD) binding to spermatids and spermatozoa reflects the extent of the change in nuclear chromatin which occurs during spermiogenesis. Therefore, the kinetics of binding to the deoxyribonucleoprotein (DNP) of live, morphologically abnormal, testicular and ejaculated spermatozoa from five infertile and three control bulls have been studied by the use of quantitative autoradiography in order to examine suspected defects in the nuclear chromatin and particularly in the binding of nuclear protein to DNA.
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