Patients with NF-PanNET-G1 have a very low risk of pN+ in the absence of radiological signs of node involvement. When preoperative grading assessment is not achieved, the radiological size of the lesion is a powerful alternative predictor of pN+. The risk of pathological nodal involvement in patients with NF-PanNETs can be accurately estimated by a clinical predictive model.

In selected patients, with small and low-grade tumors, PSP are associated with excellent overall and recurrence-free survivals. These procedures are associated with an increased postoperative morbidity but an excellent postoperative pancreatic function. Therefore, they should be considered as a valid therapeutic option in selected well-differentiated pancreatic neuroendocrine tumors.

We describe an experiment in which a train of femtosecond pulses is coupled into a photonic crystal fiber (PCF) by means of an offset pumping technique that can selectively excite either the mode LP(01) or LP(11) or LP(21). The PCF presents a wide range of wavelengths in which the fundamental mode experiences normal dispersion, whereas LP(11) and LP(21) propagate in the anomalous dispersion regime, generating a supercontinuum based on the soliton fission mechanism. We find that the existence of a cut-off wavelength for the higher-order modes makes the spectral broadening asymmetrical. This latter effect is particularly dramatic in the case of the LP(21) mode, in which, by using a pump wavelength slightly below cut-off, the spectral broadening occurs only on the blue side of the pump wavelength. Our experimental results are successfully compared to numerical solutions of the nonlinear Schrödinger equation.