Background/Aim: Mammary carcinoma (MC) remains one of the leading causes of morbidity and mortality in the female population worldwide. Cold physical plasma at atmospheric pressure (CAP) has an antioncogenic effect on tumor cells, and its anticancer properties may complement or even extend existing treatment options. In the present study, the efficacy of CAP was characterized on an MC in vitro cell culture system. Materials and Methods: MC cells (MCF-7, MDA-MB-231) were directly treated with CAP or incubated with CAP-treated cell culture medium. Cell growth, cell mobility and apoptosis were subsequently analyzed. Results: A single treatment of MC cells with CAP and CAP treated medium led to a treatment-time dependent reduction of cell growth. Furthermore, CAP exposure led to a loss of cellular motility and induced apoptosis. Conclusion: Due to its anticancer properties, CAP treatment is an innovative and promising physical approach to expand and complement the treatment options for MC. In particular, a combination of CAP application with surgical and/or chemotherapeutic interventions might significantly improve the therapeutic outcomes.Physical procedures, such as radiotherapy or electrosurgery entered medicine as early as the 1990s. The technical advancement of physical plasma led to the development of another physical therapy field, 'plasma oncology' (1). Cold physical plasma under atmospheric pressure (cold atmospheric plasma: CAP) is generated by applying high electrical voltage to two electrodes through which a carrier gas flows. In contact with the surrounding atmosphere, numerous excited and charged particles, free radicals, and electromagnetic radiation with high biological reactivity are generated (2, 3). In particular, reactive oxygen and nitrogen species (ROS, RNS) are formed, which play a major role in the biological effects of CAP treatment (4). It has been shown that after treatment of tumor cells with CAP, produced antiproliferative effects in varying tumor entities including carcinomas of the lung, ovaries, pancreas, and prostate, as well as osteosarcoma (5-9). In addition, CAP possesses antimicrobial, antiseptic, immunomodulating, antiinflammatory and wound healing promoting properties (10,11), which is why CAP has also been used in the treatment of body surfaces (skin diseases including skin tumours, tumours of the oral cavity) (12). Due to the short half-life of the reactive particles, CAP effects are temporally and locally limited. The intraoperative use of CAP in surgical oncology would be a further therapeutic alternative. Furthermore, the antimicrobial and wound healing promoting properties of CAP treatment may reduce postoperative complications.The mammary carcinoma (MC) is one of the most common cancers in the female population and is the main cause of morbidity and mortality in women. Worldwide, MC is responsible for about 25% of all cancers and about 15% of all cancer-related deaths, although the incidence can vary considerably from country to country (13, 14). Five options are avail...
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