A new drug dosage form comprising activated carbon particles adsorbing mitomycin C (MMC-CH) is designed to slowly release its components, and has affinity for the tumor surface and lymph nodes and a tendency to stay long in the local portion. The therapeutic index of MMC-CH in experimental carcinomatous peritonitis is 3.1 times as high as that of MMC-solution. In clinical experiments 81 patients with carci-nomatous effusions were administered with MMC-CH (2.0-2.4 mg/kg in terms of MMC) in bolus in-tracavitarily. Fifty-one patients responded well to the MMC-CH therapy. Nineteen patients were alive for more than 6 months. The responders showed marked improvement in subjective symptoms, and 26 patients became dischargeable from hospital. Bone marrow suppression and peritoneal irritation were main adverse effects, but the symptoms were temporary and not so serious in spite of a high dose of MMC. Cancer 59:245-251, 1987. OR CARCINOMATOUS peritonitis or pleuritis, many F kinds of anticancerous agents in solution form have been administered intracavitarily. These methods are not always successful to control the local lesion, because therapeutic agents injected intracavitarily in solution form are easily absorbed through the large serosal surface into blood plasma and it is difficult to keep a high concentration of the agents for a long time in the ~ a v i t y. ~ To surmount this difficulty we have decided to utilize the functional slow-releasing ability of adsorbents, and devised a new dosage form, called MMC-CH,6 comprising fine activated carbon particles adsorbing mitomycin C (MMC). Experiments with animals have shown that MMC-CH slowly releases its components, and has affinity for the tumor surface and lymphatics, and a tendency to stay long in the cavity. Rat experiments indicate that MMC-CH has higher therapeutic effects on experimental carcinomatous peritonitis than MMC-solution.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.