This article describes a new approach for the detection and identification of a molecular interaction in real‐time and non‐label with surface plasmon resonance (SPR). This approach is based on the transverse resonance method, modeling the nanobiosensor by an equivalent circuit that allows studying the dispersion characteristics of surface plasmon and the reflectivity. The results obtained from these two studies show that the dispersive study is very precise than the reflectivity one to determine the presence and nature of molecular interactions.
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